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Amitriptyline

Please note: Brand received may vary

Amitriptyline is a drug that belongs to the tricyclic antidepressant family of medicines, but is rarely used to treat depression. Instead, amitriptyline is used to treat a variety of conditions including nerve pain and migraines. Currently, NICE guidelines recommend amitriptyline as a first line treatment for nerve pain, and doctors often recommend it before other drugs such as pregabalin and gabapentin.

The active ingredient is amitriptyline hydrochloride, and it’s recommended to take the lowest effective dose for the shortest time possible.

If you’re looking to buy amitriptyline in the UK, please complete a consultation for neuropathic pain and one of our doctors will review your answers.

See Amitriptyline Patient Information Leaflet

Last PIL Review Date: 11/03/2019

Prices start at £19.99 for 28 tablets

£ 19.99 InStock
In stock
SKU
Amitriptyline
PLEASE CLICK HERE TO ANSWER SOME QUESTIONS ABOUT YOUR SYMPTOMS
Please note all the answers are reviewed by a doctor to assess eligibility
1
2
3

Please use a minimum of 10 words.

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5
  • Adrenaline/epinephrine
  • Bupropion
  • Cinacalcet
  • Dronedarone
  • Ephedrine
  • Fluoxetine
  • Fluvoxamine
  • Isocarboxazid
  • Lithium
  • Moclobemide
  • Noradrenaline/norepinephrine
  • Paroxetine
  • Phenelzine
  • Terbinafine
  • Phenylephrine
  • Tranylcypromine
6
  • Unexpected weight loss
  • Change in bowel habit
  • Abnormal sweating
  • Unexpected bleeding
  • Feeling unwell in yourself
7

Please use a minimum of 30 words.

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  • Pain or numbness in both your legs
  • Numbness in your anal area
  • Urinary incontinence
  • Faecal incontinence
  • Loss of sexual function in yourself
9

Where "0" is no pain and "10" is the worst pain you have ever had.

10

Please use a minimum of 10 words.

11

Please use a minimum of 20 words.

12

Please use a minimum of 30 words.

13

This includes:

  • X-Ray
  • MRI scan
  • CAT scan
  • Blood tests

Please use a minimum of 20 words.

14

Exercise such as:

  • Yoga
  • Pilates
  • stretches
  • walking
  • cycling

Please use a minimum of 10 words.

15
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  • depression
  • muscle weakness
  • Myasthenia
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For example:

  • physiotherapy
  • osteopathy
  • acupuncture
  • chiropractic
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  • You will read the Patient Information Leaflet supplied with your medication
  • You will contact us and inform your GP of your medication if you experience any side effects of treatment, if you start new medication, or if your medical conditions change during treatment
  • The treatment is solely for your own use
  • You are over the age of 18 and you have entered your own information for our identity verification checks
  • You have answered all the above questions accurately and truthfully
  • You understand our doctors take your answers in good faith and base their prescribing decisions accordingly, and that incorrect information can be hazardous to your health
  • You will inform your own GP of this purchase if appropriate
  • You are happy for your consultation to be reviewed by a European doctor company, and as such it is not subject to CQC Registration or inspection in England. (Please note all of our medicines are dispensed from a fully licensed and regulated UK Pharmacy).
  • You have read our privacy policy, cookie policy, patient agreement, data sharing agreement and Terms & Conditions
Other Treatments Include
Online consulting and prescribing service
Dispensing of prescriptions and supply of medicine
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Dr. Diana Gall GMC No. 7685129

Dr Diana Gall graduated from medical school in 2005 and has since undertaken further intensive training in many different areas of medicine. Dr Driana has reached consultant level and has practiced medicine all over Europe.

Shamir Patel GPHC No. 2049338

Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

Amitriptyline uses

In the UK, amitriptyline is licenced for neuropathic pain, the prevention of migraines, and the prevention of chronic tension-type headaches. Amitriptyline’s many uses means that it’s a drug used by several groups of people to help to improve their symptoms. Amitriptyline is also licensed to treat major depressive order in adults, but it isn’t recommended for this, and certainly isn’t routinely prescribed until many other treatments have been exhausted without success.

Amitriptyline can also be used off-label to treat adults with abdominal pain/discomfort that haven’t responded to laxatives, loperamide or antispasmodics. Off-label means that although the medicine isn’t licenced for the treatment of that particular condition, it can be prescribed for it if your doctor thinks it’s suitable. To find out more about medications being used off label, please see these government guidelines.

Amitriptyline for pain

Amitriptyline’s most common use is for neuropathic pain. This type of pain is caused by damage or injury to the nerves, and can range from stabbing and shooting to burning and pricking, though the sensations can differ from person to person.

Amitriptyline for pain often works better than analgesics, opiates, and NSAIDs, due to the fact that the drug is generally prescribed to nerve pain that doesn’t respond to traditional methods. Amitriptyline works within the central nervous system, making it a popular and effective treatment for patients struggling with neuropathy.

How does amitriptyline work

Amitriptyline for pain relief works within the central nervous system, encompassing the brain and spinal cord. As it’s a tricyclic antidepressant, it increases the amount of certain neurotransmitters – serotonin and noradrenaline.

These two neurotransmitters act as messengers between the brain and the nerves, and are linked with mood, appetite, sleep and wake cycles, and pain relief.

By increasing the amount of these neurotransmitters, amitriptyline relieves nerve pain by reducing the amount of pain signals sent to the brain. It also helps your muscles to relax, relieving you of any unnecessary tension that might be making your condition even worse. You can still use other medicines such as NSAIDs and analgesics alongside amitriptyline for pain management.

How long does amitriptyline take to work

Most painkillers work within around half an hour of you taking them. Unfortunately, amitriptyline isn’t fast-acting, and you’ll need a little patience to feel the benefits of the drug.

When taken regularly as directed, you should start to feel better within around 6 weeks of treatment. Whilst amitriptyline might not get rid of all of your pain, it can make it more bearable and allow you to manage daily activities. We understand that 6 weeks can be a long time to wait when you’re experiencing nerve pain, but luckily, amitriptyline won’t interact with medicines such as paracetamol, ibuprofen, naproxen and codine, meaning that your doctor can still prescribe more traditional pain relief to tide you over until the amitriptyline begins to work.

Amitriptyline for sleep

Amitriptyline isn’t licensed to treat any sleep disorders. However, it has been known to cause drowsiness and improve the sleep quality for nerve pain patients, though this may be partly to do with reduced pain levels.

If you’re looking for amitriptyline to treat a sleep disorder you may have, please take a look at our insomnia page for more information about the condition, and what alternative treatments are available. Your own doctor may be able to prescribe amitriptyline for sleep as an off-label use, but you’ll usually have to exhaust all other avenues of treatment, including zolpidem and circadin.

Is amitriptyline safe

Amitriptyline is a prescription drug, meaning that it carries risks. However, given that it’s recommended as a first line treatment for people with nerve pain, it’s generally a fairly safe drug to take as long as you stick to the recommended dosage.

As with any medicines, there are certain groups of people that aren’t able to take amitriptyline, and should see their GP for advice on alternative treatments. If you have any of the problems or conditions listed below, you shouldn’t buy amitriptyline, and should make an appointment with your doctor instead:

  • Allergic to amitriptyline or any of the ingredients
  • Recent heart attack
  • Any heart problems at all
  • Taking MAOIs
  • Taken moclobemide in the last 24-48 hours
  • Liver disease

Due to the way amitriptyline works in the body, there are also several medicines that can interact with it, meaning that it could cause dangerous interactions. If you’re taking any of the medicines listed on the table below, please make an appointment with your doctor to discuss whether amitriptyline is safe for you to take.

Adrenaline
Altretamine
Amiodarone
Anaesthetics
Andverapamil
Apraclonidine
Astemizole
Atropine
Baclofen
Betanidine
Brimonidine
Carbamazepine
Cimetidine
Cisapride
Clonidine reserpine
Diltiazem
Disopyramide
Disulfiram
Diuretics
Ephedrine
Fluconazole
Fluoxetine
Fluvoxamine
Glyceryl trinitrate
Guanethidine
Halofantrine
Hyoscyamine
Iproniazid
Isocarboxazid
Isoprenaline
Isosorbide sinitrate
Itraconazole
Ketoconazole
Methadone
Methyldopa
Methylphenidate
Nefopam
Nialamide
Noradrenadline
Opioids
Oral contraception
Ortanylcypromide
Paroxetine
Phenelzine
Phenylephrine
Phenylpropanolamine
Phenytoin
Pimozide
Propafenone
Quinidine
Rifampicin
Ritonavir
Sedatives
Selegiline
Sertindole
Sibutramine
Sotalol
St John’s Wort
Terbinafine
Terfenadine
Thioridazine
Thyroid medication
Tramadol

If nothing above applies to you, amitriptyline should be safe for you to take for the relief of nerve pain.

Amitriptyline side effects

Amitriptyline can cause some unpleasant side effects, but many people find that the benefits of the drug outweigh the symptoms that it might cause. Some people don’t experience any side effects at all, whilst others may feel mild discomfort in relation to amitriptyline. However, if you feel as though you aren’t coping with the side effects or that you can’t tolerate the drug, please see your GP to explore alternative treatment options. The side effects listed below aren’t exhaustive, so please make yourself familiar with the patient information leaflet (PIL) so you’re aware of what may happen before you buy amitriptyline.

Drowsiness
Headache
Constipation
Weight gain
Congested nose
Attention disturbances
Disturbed concentration
fatigue
urination disorders
Shakiness
Irregular heartbeat
Nausea
Slurred speech
Confusion
Changed taste
Dilated pupils
Low blood sodium
Feeling thirsty
Dizziness
Dry mouth
Excessive sweating
Aggression
Sexual disturbances
Numbness/tingling
Heart block
Agitation
Risk of bone fractures

Amitriptyline weight gain

Weight gain is listed as a common side effect on the patient information leaflet for amitriptyline. This means that during clinical trials, more than 1 in 10 people experienced weight gain whilst taking amitriptyline.

If you’re worried about putting on weight whilst taking amitriptyline for pain, you should make an appointment with your doctor or dietician to discuss what you can be doing to stay at a healthy weight.

If you’re reading this because you’ve already gained weight with amitriptyline, there are things you can do to help yourself lose weight, such as eating a balanced diet and making sure you get enough exercise. However, if you’ve already tried this without success, and have a BMI of over 28, there may be some weight loss medications that could help you, make an appointment with your doctor to find out more.

Amitriptyline dosage

Amitriptyline generally comes in three doses:

  • Amitriptyline 10mg
  • Amitriptyline 25mg
  • Amitriptyline 50mg

Most doctors will recommend taking the lowest effective dose for the shortest amount of time possible, so it’s likely that you’ll be started on amitriptyline 10mg, once daily. This dose can be increased after some time if you feel that it isn’t helping you, and for nerve pain, your doctor can increase it up to a maximum of 75mg daily.

Amitriptyline should be taken in the evening due to the fact it can make you drowsy. However, some people take the drug twice a day. If you find that an evening dose doesn’t suit you, you can ask your local pharmacist if you can change the time of day that you take amitriptyline.

Buy amitriptyline

If you’re wanting to buy amitriptyline, there are several options available to you. You can get it on the NHS from your regular GP, or you can find it online from reputable prescribers such as Doctor4U. Deciding to buy amitriptyline from the internet can be scary if it’s your first time ordering medicine online, but with Doctor4U you can be assured that you’re in safe hands.

When you buy amitriptyline, or any other medicine from us, you have to complete a consultation regarding your condition before choosing your treatment. One of our doctors will review your answers and decide whether your chosen medicine is suitable for you based on your consultation. If it is, they’ll generate an electronic prescription and your order will be sent to you via your chosen delivery method.

If you decide to buy amitriptyline from an online prescriber, you should always look for a clickable logo that says “click to verify if this website is operating legally”. Ours can be found in the footer of our website on every page, and it should take you to our registration page in the MHRA database (the government regulators for medicines and healthcare products).

Dosage Instructions
No
Take ONE daily at night. If required increase to a max. dose of TWO at night. IF pain not relieved please see your own GP
Active ingredient: Amitriptyline Hydrochloride
Amitriptyline Dosage Quantity Cost Including Consultation
Amitriptyline 10mg 28 Tablets £19.99
Amitriptyline 10mg 56 Tablets £29.99
Amitriptyline 10mg 84 Tablets £39.99
Amitriptyline 25mg 28 Tablets £19.99
Amitriptyline 25mg 56 Tablets £29.99
Amitriptyline 25mg 84 Tablets £39.99
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Delivery Charges

The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

UK Standard Delivery, £1.99

Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

standard UK delivery within 3-5 working days

Additional terms and conditions apply.

UK Express Delivery, £2.99

Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, £14.99

Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply

DPD Saturday Delivery, by 12:00am, £21.99

Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, by 10:30am, £29.99

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply, please see below.

US and outside the UK

Unfortunately, we can't process orders from outside the UK at this time.


Terms and Conditions

Delivery options exclude Bank Holidays, public holidays and Sundays.All deliveries are subject to Doctor-4-u successfully receiving payment and prescription being approved by the doctor.

All purchases require additional approval, which will involve completion of an online questionnaire and any subsequent approval.

Active ingredient: Amitriptyline Hydrochloride
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