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Avomine

Avomine is a first-generation antihistamine that also acts as an antiemetic. It’s used for the treatment of nausea and vomiting associated with travel sickness and nausea. It contains Promethazine, which blocks histamine from binding with receptors in the vomiting centre of the brain, which is responsible for feelings of nausea and for the vomiting reflex. As histamine can’t bind with these receptors, the vomiting centre isn’t activated and you shouldn’t experience the symptoms associated with motion sickness

Avomine can make you drowsy, so make sure you know how the drug makes you feel before you drive. It may be that you aren’t able to drive, or need to switch to another, non-drowsy medication.

Avomine can be bought from pharmacies at the lower strength, but the higher strength requires a prescription. You can do this online through Doctor4U, subject to doctor approval and completion of a patient questionnaire.

Patient Information Leaflet Updated on: 14/01/2020



See Avomine Patient Information Leaflet

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  • MAOIs for depression
  • Anticholinergic medicines
  • Medicines for depression
  • Medicines to help you sleep
  • Aspirin and similar medications
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Please use a minimum of 1 words.

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  • Asthma
  • bronchitis
  • Epilepsy
  • Heart rpoblems
  • Liver or kidney problems
  • Stomach blockage
  • Difficulty urinating
  • Hearing problems
  • Glaucoma
  • Reye's syndrome
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Please use a minimum of 1 words.

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  • For travel sickness, you should take 20mg of promethazine the night before your journey. You can then repeat this 6-8 later if needed
  • Promethazine may cause drowsiness. You shouldn't take it if you're expecting to drive
  • You should avoid unnecessary exposure to sunlight whilst taking promethazine
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  • You have an allergy or hypersensitivity to promethazine
  • You've used this treatment before and suffered from serious side effects
  • You're using promethazine for a condition other than travel sickness
  • You're taking another medication for travel sickness, or another drug that can cause drowsiness
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Dr. Daniel Cichi GMC No. 6163403

Dr Daniel Cichi has 20 years experience as a doctor and now he is a senior GP. He worked in A&E departments, GP surgeries and on cruise ships.

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Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

What is Avomine?

Avomine is an antiemetic drug that’s used for the treatment of nausea and vomiting associated with motion sickness or vertigo. It contains the medicine Promethazine, which is a first-generation antihistamine. Whilst antihistamines are most commonly used to treat symptoms of allergies, Avomine is very effective at preventing or treating nausea and vomiting in relation to motion sickness.

What is travel sickness?

Travel sickness happens when your brain receives mixed messages from the eyes and inner ear. Your eyes tell the brain that your surroundings are stationary and stable, whilst bumps in the road or choppy seas cause your inner ear to tell your brain that you’re moving. This causes a conflict in messages and triggers the vomiting centre in the brain. This is when you start to feel nauseous and want to vomit. However, treatments such as Avomine exist to reduce these feelings and make travelling a more pleasant experience.

Travel sickness can happen whether you’re on the road, on a train, plane, or sailing on a boat, as all of these activities can cause the mixed signals to reach your brain due to the unexpected movements.

How does Avomine work?

Avomine stops histamine from binding to receptors in the vomiting centre of the brain. The vomiting centre, as we’ve already learnt, is responsible for nausea and the vomiting reflex, and is activated when it receives mixed messages. If histamine doesn’t bind to these receptors in the brain, the vomiting centre isn’t activated and you shouldn’t feel any symptoms associated with travel sickness.

Can I take Avomine?

There are some groups of people that should take care when using Avomine, or even completely avoid the medication altogether. Those that should take caution and speak to their GP before ordering include those who:

  • Are allergic to promethazine or any other ingredients of Avomine
  • Are taking a medicine for depression called a monoamine oxidase inhibitor (MAOI) or have taken it in the last 2 weeks.
  • Have difficulty breathing, are wheezing, have a tight chest or bronchitis
  • Are epileptic
  • Have serious heart problems
  • Have liver or kidney problems
  • Have a stomach blockage or difficulty passing urine
  • Have hearing problems
  • Have increased pressure in the eye
  • Have been diagnosed with (or are suspected to have) Reye’s syndrome.

If any of the above conditions or problems apply to you, you shouldn’t order Avomine before speaking to your GP or local pharmacist first. This medicine may not be the most suitable option for you, and there are other treatments out there for motion sickness.

There are also some medicines that might interact with Avomine, and taking them together might cause adverse effects. If you’re taking any of the following medications, please see your GP or pharmacist before starting treatment with Avomine:

  • Anticholinergic medicines
  • Some antidepressants
  • Sedatives
  • Hypnotics
  • Muscle relaxants
  • Aspirin

What are the side effects of Avomine?

Avomine can cause some unpleasant side effects, and it’s up to you to decide whether the benefits of the medicine outweigh the side effects. Not everyone experiences them, and those that do often only notice them mildly, but it’s important to make yourself familiar with the patient information leaflet and all potential symptoms associated with the medicine. Some of the most common ones are:

Allergic reaction
Long-lasting infections
Unexplained bruising
Nose bleeds
Jaundice
Headache
Dizziness
Restlessness
Confusion
Fatigue/drowsiness
Blurred vision
Dry mouth
Difficulty urinating
Loss of appetite
Stomach upset
Cramp/muscle spasms
Unusual movement of head
Unusual movement of facial muscles

If you decide that the side effects are worse than the travel sickness, stop taking the medicine and ask a pharmacy if there are any alternatives that you can take.

How do you take Avomine?

There are several ways of taking avomine depending on whether you’re preventing or treating nausea and travel sickness, and whether you’re on a long or short journey. Let’s explore the different options:

  • Prevention for a short journey: take one tablet 1-2 hours before you travel.
  • Prevention for a long journey: take one tablet each night at bedtime, starting the night before you travel (ideal for cruises)
  • Treatment of travel sickness/nausea: take one tablet when you start to feel sick, then another tablet later that same evening. If you need to, you can take a third tablet the evening after.

If you find that Avomine isn’t working, a doctor might suggest increasing your dose or switching to another medication.

Can you drive while taking Avomine?

Avomine is known to cause drowsiness in some people, so we would advise that you don’t drive until you know how the drug makes you feel. If you find that you don’t feel drowsy, dizzy or confused at all, you may be able to drive at some point in your journey. However, we’d suggest to err on the side of caution and not drive if you’ve taken Avomine (or to avoid taking the medicine if you know you’ll be driving at some point in the journey).

Buy Avomine

You can buy Avomine and other remedies for travel sickness online from Doctor4U. Before you buy Avomine, you’ll need to complete a short form about your symptoms so that we can make sure that it’s suitable for you to take.

Buying avomine online is quick and easy with Doctor4U, and you’re guaranteed a confidential and professional service, as you’d expect from your own doctor.

Buying Avomine from Doctor4U means that you don’t even need to leave your house - just order at a time to suit you and your treatment will get delivered to your door

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