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High Blood Pressure

Cardioplen XL

Cardioplen XL is a calcium-channel blocker that dilates the blood vessels and arteries in patients that suffer with high blood pressure or angina. It works by blocking the calcium supply to the muscles surrounding the blood vessels and arteries (they need calcium to be able to contract). This then allows the blood vessels and arteries to widen, allowing blood to flow more easily to and from the heart.

Cardioplen XL aren’t the same as ACE inhibitors, but they have the same end-goal of dilating your blood vessels to lower and control your high blood pressure.

Last PIL Review Date: 23/01/2020

See Cardioplen XL Patient Information Leaflet

This medicine is not available to request via our online service. If you are still having trouble with your symptoms please visit the NHS website for services in your area.


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Dr. Diana Gall GMC No. 7685129

Dr Diana Gall graduated from medical school in 2005 and has since undertaken further intensive training in many different areas of medicine. Dr Diana has reached consultant level and has practiced medicine all over Europe.

Shamir Patel GPHC No. 2049338

Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

What is Cardioplen XL?

Cardioplen XL is a medication that’s prescribed to patients with high blood pressure, and sometimes angina. It contains felodipine, which is a calcium-channel blocker, acting on the cardiovascular system.

It works in a different way to ACE inhibitors, but still has the same desired effect of lowering blood pressure.

Cardioplen works by slowing down the movement of calcium through the muscle cells in the walls of blood vessels. Because muscle cells need calcium for them to be able to contract, blocking the calcium supply relaxes them, and allows the blood vessels to completely dilate. This means that blood isn’t being forced through narrow vessels, but is flowing freely.

For angina, Cardioplen works in a similar way, but instead allows the arteries to widen to let more blood and oxygen reach the heart.

Cardioplen helps the heart, as it makes it easier for blood to flow to and from it.

Can I take Cardioplen XL?

Cardioplen XL does have quite a large impact on your body, so there are certain conditions which might not be compatible with the medication. People with some health problems might be risking their overall health if they take Cardioplen XL, so if you have any of the following conditions or medical problems, please make an appointment with your doctor first to find out whether Cardioplen XL would be a safe option for you:

  • Allergic to cardioplen
  • Previous allergy to similar medications such as amlodipine, nisoldipine and nifedipine
  • Pregnant
  • Breast feeding
  • Narrowing of the aortic valve in the heart
  • Collapse caused by a heart problem
  • Severity of frequency of symptoms has increased suddenly
  • Heart attack in the last month
  • Severe heart problems
  • Uncompensated heart failure
  • Low blood pressure with abnormal rapid heart beats
  • Poorly functioning left ventricle
  • Liver problems
  • Swollen gums

You should also be aware of the symptoms of extremely low blood pressure, as it’s not only unsafe to take this medication with this condition, but it’s also a medical emergency and you should call 999 if you experience dizziness and chest pain.

If none of the above conditions apply to you, you might be a suitable candidate for using Cardioplen XL to treat your high blood pressure or angina.

Does Cardioplen XL interact with any other drugs?

Yes. Cardioplen shouldn’t be taken alongside certain medications as they might affect how each other works in your body. This could mean that one of your treatments isn’t as effective, or it could increase the risk and severity of side effects. The medications listed as potential interactions are:

  • Any other blood pressure lowering medications
  • Barbiturates
  • Carbamazepine
  • Cimetidine
  • Efavirenz
  • Erythromycin
  • Grapefruit juice
  • Itraconazole
  • Ketoconazole
  • Nevirapine
  • Phenytoin
  • Ritonavir
  • St John’s Wort
  • Tacrolimus

The list has been alphabetised for you to find any of your current medicines on the list, but we’ll also list some of the families of medicines and conditions that they treat, so if you’re on any other drugs for the same problem and are unsure of whether you can take Cardioplen XL, you can take a list of your current drugs to your local pharmacist for them to check for interactions.

  • Stomach ulcers
  • Antibiotics
  • Fungal infections
  • Protease inhibitors
  • HIV
  • Organ transplant
  • High blood pressure
  • Anxiety
  • Sleeping disorders
  • Epilepsy

If you’re taking any medications that are listed above, or that belong to any of the same families, please talk to your doctor and local pharmacist to see if it’s safe for you to add cardioplen XL to your medication regime.

What are the side effects of Cardioplen XL?

There are several side effects that might be experienced once you start cardioplen XL, but some people either don’t get them at all, or only feel them to a mild degree. Your doctor would only prescribe this medication to you if they thought that the benefits of it would outweigh the potential side effects you might feel. Some of the most commonly reported symptoms associated with using Cardioplen are:

  • Ankle swelling
  • Headache
  • Flushing
  • Abnormally rapid heartbeat
  • Burning/prickling/numbness
  • Rash
  • Itching
  • Fatigue
  • Dizziness
  • Fainting
  • Vomiting
  • Nettle rash
  • Pain in joints
  • Muscular pain
  • Impotence
  • Gingivitis
  • Increased liver enzymes
  • Photosensitivity
  • Inflammation of small blood vessels under the skin
  • Need to urinate frequently
  • Allergic reaction

If any of the side effects bother you more than the original complaint, you should visit your doctor to ask about alternative treatments. There may be other medicines available to help you cope with the side effects if your doctor believes that Cardioplen XL is the best treatment for you.

If you do experience a severe allergic reaction known as anaphylaxis, you should call 999 and state that you’re having a severe allergic reaction to Cardioplen XL. This is rare, but still a possibility, as with most medicines.

You should also seek emergency help and call 999 if you experience chest pains when first using Cardioplen.

Always tell your doctor if you experience any side effects.

How else can I lower my blood pressure?

There are ways to try and lower your blood pressure alongside using medication. These include making small lifestyle changes such as:

  • Losing weight
  • Taking regular exercise
  • Eating a healthy diet
  • Reducing the sodium in your diet
  • Limiting your alcohol intake
  • Stopping smoking
  • Reducing your caffeine intake
  • Reducing stress

You should try to adopt any and all of the points above that apply to you to try and control your blood pressure alongside your medication. Sometimes, this is enough on its own, but other times, your doctor may just slightly decrease your dosage if your efforts at lifestyle changes are successful at controlling your blood pressure.

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Delivery Charges

The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

UK Standard Delivery, £1.99

Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

standard UK delivery within 3-5 working days

Additional terms and conditions apply.

UK Express Delivery, £2.99

Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

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Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

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Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, £14.99

Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply

DPD Saturday Delivery, by 12:00am, £21.99

Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, by 10:30am, £29.99

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply, please see below.

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