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Celebrex

Celebrex is a brand of non-steroidal anti-inflammatory drug (NSAID) that contains the ingredient celecoxib. It’s manufactured by Pfizer and helps many people that struggle with several types of arthritis as well as acute pain.

In trials, its effectiveness was comparable to another, popular NSAID, naproxen.

With painful conditions where inflammation is present (such as with arthritis), prostaglandins might be produced in excess, contributing to the amount of pain a patient might feel. Celebrex blocks the enzyme that produces these prostaglandins, relieving symptoms of pain and inflammation.

Last PIL Review Date: 24/01/2020

See Celebrex Patient Information Leaflet

This medicine is not available to request via our online service. If you are still having trouble with your symptoms please visit the NHS website for services in your area.

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  • Dextromethorphan
  • ACE inhibitors
  • Angiotensin II antagonists
  • Beta blockers
  • Diuretics
  • Fluconazole
  • Rifampicin
  • Warfarin
  • Apixaban
  • Anticoagulants
  • Acetylsalicylic acid
  • Lithium
  • Medicines to treat depression
  • Medicines for sleep disorders
  • Medicines for high blood pressure or arrythmia
  • Neuroleptics
  • Methotrexate
  • Carbamazepine
  • Barbiturates
  • Ciclosporin
  • Tacrolimus
  • Antiplatelet therapies
  • Other NSAIDs
  • Corticosteroids
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  • Allergy to celecoxib
  • Allergy to sulfonamides
  • History of stomach ulcer or bleeding in the stomach or intestines
  • History of adverse reaction to NSAIDs or acetylsalicylic acid
  • Pregnant or breast feeding
  • Liver or kidney disease
  • Inflammatory bowel disease such as Crohn's or ulcerative colitis
  • Any heart problems at all
  • Issues with blood circulation
  • History of surgery on the arteries at the top of your leg
  • Smoker
  • Diabetes
  • High cholesterol
  • Fluid retention
  • Dehydrated
  • Over 65
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  • NSAIDs may slightly increase your risk of heart attack. The risk is greater with high doses or when the medication is taken for prolonged periods of time. You should speak to your own GP if you have any concerns abotu this. 
  • NSAIDs may also cause gastrointestinal symptoms. Becuase of this, you should always take them with food to avoid this risk as much as possible. Your own GP may also recomment that you take a proton pump inhibitor such as omeprazole to protect the stomach. You should ask your doctor for more advice on this and if it's something that's suitable for you.
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Please use a minimum of 1 words.

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  • NSAIDs may slightly increase your risk of heart attack. The risk is greater with high doses or when the medication is taken for prolonged periods of time. You should speak to your own GP if you have any concerns about this. 
  • NSAIDs may also cause gastrointestinal symptoms. Becuase of this, you should always take them with food to avoid this risk as much as possible. Your own GP may also recomment that you take a proton pump inhibitor such as omeprazole to protect the stomach. You should ask your doctor for more advice on this and if it's something that's suitable for you.
  • Celecoxib may increase your blood pressure. Because of this, your GP may want to monitor you on a more regular basis. You should tell your GP that you're taking celecoxib, and also report any change in blood pressure to your own doctor immediately.
  • Celecoxib may make it difficult to become pregnant. If you're trying to conceive, you should speak to your doctor about whether or not celecoxib is suitable for you. 
  • Celecoxib may cause dizziness or drowsiness in some people. If this happens to you, you should not drive or operate machinery until the feeling subsides. 
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  • You have an allergy to celecoxib
  • You've used this treatment in the past and suffered with serious side effects
  • You're already using a treatment that contains celecoxib for any other reason than pain relief
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What is Celebrex?

Celebrex is a brand of pain medication manufactured by Pfizer. It contains the ingredient celecoxib and is an NSAID (non-steroidal anti-inflammatory drug). It’s prescribed for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute pain. Celebrex relieves pain and inflammation.

How does Celebrex work?

As an NSAID, Celebrex blocks the enzyme that produces prostaglandins. These prostaglandins can cause pain and inflammation, so the reduction of them can help to decrease and relieve these symptoms. Patients with various types of arthritis often produce more prostaglandins, hence why the conditions can be very painful.

Can I take Celebrex?

NSAIDs can be dangerous medications if taken by people with certain conditions, so there are some patients that should take extra care when using Celebrex. You should avoid using the medication until you’ve spoken to your own GP if you have any of the following conditions, symptoms, or medical problems.

  • Allergy to Celebrex
  • Angina
  • Blockage of blood vessels to the heart or brain
  • Breast feeding
  • Currently bleeding in the stomach or intestines
  • Currently have a stomach ulcer
  • Dehydrated
  • Diabetes
  • Feeling ill due to an infection (Celebrex might mask the illness)
  • Fluid retention
  • Heart disease
  • Heart failure
  • High blood pressure (hypertension)
  • High cholesterol
  • If you’ve ever developed asthma or sinus issues as a result of taking NSAIDs
  • Inflammatory disease of the intestines
  • Mini stroke (TIA)
  • Over 65
  • Pregnant
  • Previous allergic reaction to sulphonamides (some antibiotics)
  • Previous serious allergy to any medicines
  • Previous stomach ulcer
  • Problems with blood circulation
  • Severe kidney disease
  • Severe liver disease
  • Smoker
  • Stroke
  • Surgery on leg arteries
  • Taking acetylsalicylic acid
  • Taking anticoagulants
  • Trying to conceive
  • Using any other NSAIDs

If any of the above apply to you, please speak to your GP at the earliest opportunity to discuss your treatment options. You may be able to take a lower dose of Celebrex, or be advised to avoid the medicine completely and offered alternative treatments.

Does Celebrex interact with any other medicines?

Celebrex should be taken with caution (or even completely avoided) if you’re taking some other types of medicines. If taken together, they can cause potentially dangerous interactions. If you know that you take any of the medicines listed below, speak to your local pharmacist or make an appointment with your GP to discuss the safety of taking the medicines together.

  • ACE inhibitors
  • Angiotensin II agonists
  • Anticoagulants
  • Barbiturates
  • Beta blockers
  • Carbamazepine
  • Ciclosporin
  • Dextromethorphan
  • Diuretics
  • Fluconazole
  • Lithium
  • Medicines for an irregular heartbeat
  • Medicines for depression
  • Medicines for hypertension
  • Medicines for sleep disturbances
  • Methotrexate
  • Neuroleptics
  • Rifampicin
  • Tacrolimus

We’ve sorted the list into alphabetical order so you can quickly look to see if you’re taking any of the medicines on the list. If you’re using a branded version of a medicine, check the packaging to find the active ingredient and compare it against the list.

What are the side effects of Celebrex?

Celebrex can cause many side effects, and it isn’t a medicine to be taken lightly. Taking Celebrex can have some serious consequences, which is why it’s so important to make sure with your GP that you can take the drug. Some of the most common side effects reported with patients that used Celebrex in a clinical study are:

  • Diarrhoea
  • Difficulty swallowing
  • Dizziness
  • Fluid retention
  • Headache
  • Heart attack
  • High blood pressure/worsening of existing hypertension
  • Indigestion
  • Itching
  • Muscle stiffness
  • Nausea
  • Painful joints
  • Rash
  • Shortness of breath
  • Sinusitis
  • Sleep disturbances
  • Swelling of the ankles, legs, feet and hands
  • Upset stomach
  • Urinary infections
  • Vomiting
  • Wind
  • Worsening of existing allergies

There’s also a chance that Celebrex may cause a severe allergic reaction, but the same risk is there with any other medicines.

There are some extremely serious side effects that you need to be aware of before you start treatment, as if you experience any of the following complaints, you should contact your doctor immediately or go to your nearest A&E department:

  • Allergic reaction
  • Black stools
  • Heart problems such as pain in the chest
  • Liver failure
  • Severe stomach pain
  • Skin reaction
  • Vomiting blood

There are more side effects listed in the patient information leaflet included with your order, but if you’re concerned about any of the side effects already listed, speak to your local pharmacist or make an appointment with your doctor. The medicine will only be prescribed to you if your doctor thinks the benefits will outweigh the potential risks.

How do you take Celebrex?

Celebrex is usually taken once or twice a day, ideally with food to avoid any gastrointestinal problems.

Celebrex comes as capsules in either 100mg or 200mg strength, and your dosage will depend on your condition and the severity of your symptoms.

You should take the capsules at the same time each day to maintain an even level of pain relief.

Although it’s prescribed for chronic conditions, it’s recommended that you only take Celebrex during times that your pain is flaring up. It isn’t intended to be used as a regular treatment, and you should use the lowest effective dose for the shortest time possible.

Can I take Celebrex if I’m pregnant?

Celebrex isn’t generally recommended for pregnant women unless your doctor thinks your condition is severe enough for it to be used.

Celebrex has been reported to cause some problems with couples that are trying to conceive. If you’re trying for a baby, you should also speak to your GP as Celebrex likely isn’t the most appropriate medication for you to take.

If you’re breast feeding, the medicine might be secreted through your milk. Always talk to your doctor if you’re unsure and explore alternative options for treatment and pain relief.

Can I take Celebrex with other pain medicines?

Celebrex can be taken with other pain medicines as long as they aren’t also NSAIDs or named in the interactions list. Talk to your pharmacist if you take any other medicines for pain relief and ask them whether it’s safe to take Celebrex in conjunction.

What’s the difference between Celebrex and other NSAIDs?

Celebrex is less likely to cause stomach upset or ulcers. Other NSAIDs such as naproxen, ibuprofen and diclofenac are known to increase a patient’s risk of developing gastrointestinal symptoms such as vomiting, diarrhoea, vomiting blood and black, tarry stools (indicative of a stomach ulcer). Celebrex isn’t as likely to cause these symptoms but still provides the pain relief of other NSAIDs.

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If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

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