UK icon
UK Registered Pharmacy
head shoulders icon
Friendly Patient Support
padlocks icon
100% Confidential Service Guarantee
Order in the next to receive order by

*select next day delivery at checkout. Subject to doctor approval


Differin is a medicine used as a treatment for acne symptoms. It can come in the form of either a white cream or gel, but in either form the method for using it is the same. When applied to relevant areas of the skin, this treatment prevents the blockage of oil the skin naturally produces to keep itself moisturised.

See Differin Cream Patient Information Leaflet

See Differin Gel Patient Information Leaflet

Last PIL Update: 08/03/2019

£ 29.99 InStock
In stock

These can include:

  • Eczema
  • Rosacea
  • Psoriasis

Please use a minimum of 10 words.

  • These include Differin, Epiduo and Duac
  • Irritation can be reduced by starting treatment on alternate days and building up to the prescribed dose as tolerated
  • Zineryt – antibiotic
  • Differin – retinoid
  • Epiduo – anti-inflammatory with retinoid
  • Duac – antibiotic with peeling agent (Benzoyl Peroxide)

If you experience no improvement after 4 months of using this medication, treatment should be stopped or changed.

  • Your symptoms change or get worse
  • Your acne causes scarring
  • Your acne causes you to feel depressed
  • You experience any side effects from your treatment
  • You will read the Patient Information Leaflet supplied with your medication
  • You will contact us and inform your GP of your medication if you experience any side effects of treatment, if you start new medication, or if your medical conditions change during treatment
  • The treatment is solely for your own use
  • You are over the age of 18 and you have entered your own information for our identity verification checks
  • You have answered all the above questions accurately and truthfully
  • You understand our doctors take your answers in good faith and base their prescribing decisions accordingly, and that incorrect information can be hazardous to your health
  • You will inform your own GP of this purchase if appropriate
  • You are happy for your consultation to be reviewed by a European doctor company, and as such it is not subject to CQC Registration or inspection in England. (Please note all of our medicines are dispensed from a fully licensed and regulated UK Pharmacy).
  • You have read our privacy policy, cookie policy, patient agreement, data sharing agreement and Terms & Conditions
Start consultation
Landing Banner
Online consulting and prescribing service
Dispensing of prescriptions and supply of medicine
Secure SSL Encryption

Dr. Diana Gall GMC No. 7685129

Dr Diana Gall studied medicine at the University of Transilvania graduating in 2005, since then she has finished a 3 year intensive training course in family medicine practice. In 2010 she reached the consultant level in general practice, working in Romania and in the UK. Her past experience relates to aesthetic field, occupational health and general practice.

Shamir Patel GPHC No. 2049338

Shamir is our Superintendent Pharmacist here at Doctor 4 U. Shamir is a well-respected pharmacist with extensive experience running independent high street pharmacies across the north west of England.

What is Differin?

Differin is a treatment for acne symptoms that can come in the forms of either a cream or a gel. It contains vitamin A and helps to prevent spots by unblocking pores and promoting skin cell renewal.

This treatment can be used on the face, chest or back for acne, where the skin may have lots of spots, pimples and blackheads. The body absorbs Differin in very small amounts and has little effect, except on the surface of the skin.

How does Differin work?

Differin contains an ingredient called adapalene which creates an anti-inflammatory effect to reduce soreness and irritation. When the cream or gel is applied to skin showing acne symptoms, the adapalene reduces the production of keratin skin cells which ordinarily clog up pores.

When sebaceous glands become blocked on parts of the skin, this leads to a build of sebum (the oil the skin produces to keep it moisturised), which can eventually lead to black or whiteheads being formed and later an infection or cyst. But with keratin skin cells removed, the sebum can instead exit the sebaceous cells and stop spots from forming.

How do I use Differin?

Differin is meant to be used at night shortly before going to bed. The area of skin where the cream or gel will be applied should be clean and dry before treatment. A thin film of the cream/gel is put on the affected areas with your fingertips and rubbed in gently. How long you will use this treatment for depends on how quickly your condition improves. If you’ve used this medicine for three months or longer, then it’s important to see your doctor so they can check how your condition has improved.

When Differin is in use, avoid exposure to sunlight and artificial UV light. Avoid applying the cream/gel to the eyes, mouth or nostrils. If accidental contact in these areas does occur, immediately wash with warm water.

What are the side effects of Differin?

There are several side effects that could be experienced while taking Differin in either gel or cream form. The most commonly reported issues include the following:

  • Dry skin
  • Irritation of the skin
  • Burning sensation on the skin
  • Redness of the skin (erythema)

Other side effects are much more uncommon, but the following all have some possibility of occurring while using this treatment:

  • Local skin reaction
  • Sunburn
  • Skin discomfort
  • Itchy skin
  • Peeling skin
  • Allergic contact reaction
  • Pain or swelling of the skin
  • Irritation or swelling around the eyelids

It’s best to talk to your doctor or pharmacist if you experience any side effects (whether they’re listed here or not) that cause a great deal of discomfort.

Can I use Differin?

Differin gel and cream are only intended for use on adults and adolescents aged 12 years and over. If you are pregnant or planning a pregnancy, then you should avoid using this medication. It should also be avoided if you have a skin condition called eczema.

This medicine is not designed for areas of skin where there are cuts or scrapes. An alternative treatment is better for dealing with these. If you are using any other acne products (containing benzoyl peroxide, erythromycin or clindamycin) at the time you want to use Differin, then you should be ok to use it but any other treatments should be applied in the morning, while Differing is used at night.

What if I apply too much Differin to the skin?

If you apply more of this treatment than necessary, it will not get rid of your acne at a faster rate but it does make side effects more likely. Most likely your skin can become irritated and red and some peeling could also occur.

How should Differin be stored?

Whether it’s in cream or gel form, this medication should be kept in its original container and stored somewhere that’s not above 25 degrees centigrade. This product is not to be frozen. Like with other medicines, it should be kept out of the sight and reach of children.

What if I forget to use Differin?

If you forget to use this medication on one night, then it should not create any issues so there’s no need to worry. When you remember you’re meant to be using Differin, just start using it again in the same way as before, at the appropriate time of night.

How is my order shipped to me?

When an order is ready for shipping, it is collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Each order is assigned a tracking number, which will be emailed to you at the time of dispatch. Your medicine will be sent in plain and discreet packaging that’s eco-friendly. We do not include any branding on our packaging nor any labels which inform readers what type of product is contained within.

Dosage Instructions
Dosage Instructions Apply ONCE daily, thinly to the affected area(s).
Write Your Own Review
You're reviewing:Differin

Shipping Costs

Standard UK Delivery - £1.99 - Delivery within 3-5 working days

Orders are collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Please see full postage and delivery charges here

Please Note: These prices are shown as a guide only. All delivery times are approximate but have been obtained in good faith.

Discreet Delivery

All our items are sent completely discreet for your peace of mind.

This means the packaging is plain, there is no mention of what product is inside your package and there is no mention of Doctor 4 U either.

We respect that many of our products are of a sensitive nature - this is why we take every step to keep your purchases private.

Returns Information

Customers can read our full returns policy by clicking here

No Questions