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Disulfiram

Disulfiram is a medicine used in the treatment of alcoholism. It is used by those who are in recovery and have been through a detox process, this medicine then helps prevent them from drinking alcohol. Disulfiram tablets are available under the brand name Antabuse, disulfiram being the active ingredient in Antabuse. The drug is designed to deter you from drinking alcohol in the future if you are dependent on alcohol and at risk of harm from the substance. Disulfiram should be used alongside counselling, therapy and other treatments for alcoholism.



This medicine isn't available to request via our online service. If you are still having trouble with your symptoms please visit the NHS website for services in your area. Alternatively, the Drinkaware website has some information on alcoholism.

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Dr. Diana Gall GMC No. 7685129

Dr Diana Gall graduated from medical school in 2005 and has since undertaken further intensive training in many different areas of medicine. Dr Diana has reached consultant level and has practiced medicine all over Europe.

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Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

What is Antabuse (disulfiram)?

Disulfiram treatment is a very effective deterrent against alcohol abuse and is used in the recovery process of alcoholism. Those who are alcohol dependent will go through detoxification often under medical supervision to get help with the withdrawal symptoms, as well as attending counselling and therapy to withdraw from alcohol completely. As a deterrent from drinking alcohol again, disulfiram may be prescribed as it causes severe unpleasant side effects when alcohol is in the body while taking this medicine. This means that contact with any alcoholic products including mouthwash and perfume may bring on these side effects while taking disulfiram. To help you maintain abstinence from alcohol, disulfiram is intended for use alongside counselling and therapy.

Antabuse for alcoholism - how does it work?

The active ingredient in Antabuse known as disulfiram is a type of aldehyde dehydrogenase inhibitor and works on the substance known as acetaldehyde. This substance is what alcohol turns into when it is broken down in the liver. Acetaldehyde is the culprit of hangover symptoms when large amounts of alcohol are in the body. Normally, this substance would then be broken down into acetate and then even further to leave the body. However, disulfiram blocks the enzyme which breaks down acetaldehyde, which results in high levels of the substance building up in the body and causing a severe reaction with unpleasant side effects.

These symptoms can develop within 15 minutes of alcohol entering the body and the effects can last several hours. Due to the severity of the reaction this medicine causes when in contact with alcohol, this should deter you from drinking alcohol.

Drinking after Antabuse (disulfiram)

Antabuse is only given to those who have chronic alcoholism and are serious about abstaining from alcohol. However, should you need to stop taking disulfiram you should be aware that the effects may still occur for a period after stopping this medicine. If you drink alcohol within two weeks of stopping disulfiram you may experience a reaction. If you do drink alcohol while taking disulfiram and experience a reaction, contact your doctor.

Who should not take disulfiram?

For some people, this medicine may not be a suitable treatment to help with abstaining from alcohol. Certain medical conditions or medications may prevent you from taking this medicine. You should not take disulfiram if you have:

  • An allergy to disulfiram or any other ingredient in this medicine
  • Severe heart disease or heart failure
  • High blood pressure
  • Severe psychiatric or personality disorder
  • Had a stroke
  • Recently consumed alcohol

You should also speak to your doctor before taking this medicine if you have any of the following to ensure it is safe for you to take. This includes if you have:

  • Kidney, liver, or lung disease
  • Diabetes
  • Low blood pressure
  • Brain damage
  • Epilepsy

Can other medicines affect disulfiram?

If you’re taking any other medicine either prescription or non-prescription, you should inform your doctor before starting disulfiram. Certain medicines are known to interact with disulfiram, these include:

  • Medicine to reduce blood clotting known as warfarin
  • Medicines for epilepsy - phenytoin and paraldehyde
  • Medicine to treat asthma - theophylline
  • Medicines to treat anxiety - chlordiazepoxide and diazepam
  • Painkillers - pethidine and morphine
  • Stimulants - amphetamines
  • Medicines to treat mental illness - pimozide, and chlorpromazine
  • Medicines to treat infection - isoniazid metronidazole, rifampicin
  • Medicines to treat depression - amitriptyline

If you’re taking any of these medicines check with your doctor whether disulfiram is safe for you to take.

Disulfiram side effects

Adverse side effects will occur when disulfiram is taken with alcohol, however, other side effects may be experienced without drinking alcohol although not everyone gets them. These side effects may include feeling drowsy or tired particularly when you start treatment, as well as feeling or being sick, loss of interest in sex, bad breath, and mood changes.

There is also a possibility of more serious side effects such as psychological disorders, inflammation of the liver or liver failure, pain or loss of sensation in the hands or feet caused by damage or inflammation of the peripheral nerves. It’s also possible to experience an allergic skin reaction with itching or redness.

Antabuse side effects with alcohol

When taken with alcohol, disulfiram causes a reaction with the following symptoms:

  • Flushing of the face and neck
  • High temperature
  • Sweating
  • Nausea and vomiting
  • Itchy skin or rash
  • Anxiety
  • Dizziness
  • Headache
  • Blurred vision
  • Difficulty breathing
  • Palpitations
  • Rapid breathing

What to avoid when taking disulfiram?

It’s important to be aware of what can trigger a reaction and cause severe side effects when taking disulfiram. Even a small amount of alcohol will trigger a reaction so you should avoid any foods, products or medicines containing alcohol such as vinegar, cough syrups, and mouthwashes etc. You should also avoid coming into contact with or breathing in the fumes of alcohol-containing chemicals such as in varnishes or paints. Using alcoholic products on the skin may also cause a reaction, particularly if it’s applied to an open wound, avoid using any creams, lotions, perfumes or bath products that contain alcohol as it may absorb into the body.

How to take disulfiram

Disulfiram treatment is usually started under specialist medical supervision in hospital, and you must not have drunk alcohol for at least 24 hours before taking the first dose. Disulfiram is available in 200 mg tablets and you will initially take different amounts on the first few days. The following is a guide to how disulfiram will usually be prescribed:

  • Day 1 - 4 tablets to be taken
  • Day 2 - 3 tablets to be taken
  • Day 3 - 2 tablets to be taken
  • Days 4 and 5 - 1 tablet to be taken
  • After day 5 - ½ to 1 tablet a day for as long as your doctor prescribes

Always follow your doctor’s instructions when taking this medicine, you will start off on a high dose which will gradually be reduced over the first few days.

How long do I take disulfiram for?

Your doctor will decide how long you should take disulfiram medicine for. Disulfiram may be taken long term for chronic alcohol abuse, however, it should not be taken for more than six months without having a physical checkup with your doctor.

What are the benefits of taking disulfiram?

Disulfiram is a very effective method of treating alcohol abuse. It helps manage your cravings for alcohol and allows you to properly recover from the effects of alcohol by encouraging you to abstain from the substance. As the effects kick in very soon after alcohol is in the body, drinking alcohol is simply not an option when taking disulfiram. It also reduces the risk of relapsing.

Disulfiram is so easy to take and it can be started just 24 hours after drinking alcohol, meaning you can get started on your treatment plan straight away, which is not always the case with other treatment options requiring you to be completely sober from alcohol for longer before starting treatment.

Buy disulfiram online

You need a prescription from a General Medical Council (GMC) registered doctor in order to buy disulfiram online. With Doctor-4-U’s easy consultation process, you can get a prescription for disulfiram safely and quickly. Simply click “Start Consultation” and fill out the short medical questionnaire provided. If you are deemed suitable for your prescription, it will be dispensed by our UK-based pharmacy and sent to you securely with full tracking.

How is my order shipped to me?

When an order is ready for shipping, it is collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Each order is assigned a tracking number, which will be emailed to you at the time of dispatch. Your medicine will be sent in plain and discreet packaging that’s eco-friendly. We do not include any branding on our packaging nor any labels which inform readers what type of product is contained within.

Buy Disulfiram

It isn’t possible to buy disulfiram through Doctor4U, as we believe that this is a treatment that requires regular monitoring - something that online services can’t provide.

If it’s the right treatment for you, you shouldn’t need to buy disulfiram - you should be able to access it via the NHS. Please make an appointment to see your GP to talk about your condition and the best way forward.

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Delivery Charges

The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

UK Standard Delivery, £1.99

Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

standard UK delivery within 3-5 working days

Additional terms and conditions apply.

UK Express Delivery, £2.99

Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

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Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

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Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

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Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, £14.99

Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply

DPD Saturday Delivery, by 12:00am, £21.99

Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, by 10:30am, £29.99

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply, please see below.

US and outside the UK

Unfortunately, we can't process orders from outside the UK at this time.


Terms and Conditions

Delivery options exclude Bank Holidays, public holidays and Sundays.All deliveries are subject to Doctor-4-u successfully receiving payment and prescription being approved by the doctor.

All purchases require additional approval, which will involve completion of an online questionnaire and any subsequent approval.

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