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HRT (Menopause)

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Evorel Sequi

Evorel is a form of HRT that’s prescribed to women experiencing symptoms of the menopause. It’s different to traditional forms of HRT as it comes as a patch and not as a tablet.

Evorel is ideal for women that don’t want to take medication every day, and for those that have difficulty swallowing pills.

Three types of the patch are currently available:

  • Evorel: patches that contain an oestrogen and come in various strengths and sizes.
  • Evorel Conti: patches that contain and oestrogen and progesterone (making it safe for women with a womb to use)
  • Evorel Sequi: a mix of Evorel50 (a version of Evorel) and Evorel Conti for use over the course of a month.

All of the above versions should be applied below the waistline, often to the thighs or buttocks, and never above the waist or near the breasts.

Evorel PIL

Last PIL Review Date: 13/10/2020

Prices start from £65.99 for 24 patches

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  • Jaundice (usually characterised by your skin or the whites of the eyes turning yellow)
  • Significantly increased blood pressure (you may notice headaches, dizziness, and feeling more tired)
  • New onset of migraine, which may be with or without aura
  • Chest pain that radiates to the arm and/or neck
  • Signs of a blood clot
  • Any breast changes such as dimpling, puckering, nipple discharge, or any other abnormality
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  • Epilepsy medications
  • Medicines for tuberculosis
  • HIV treatments
  • St John's Wort
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Please use a minimum of 1 words.

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Please use a minimum of 1 words.

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You have an allergy to norethisterone or estradiol You've used this treatment in the past and suffered with serious side effects You're already using a treatment that contains norethisterone or estradiol for any reason other than hormone replacement therapy
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What is Evorel?

Evorel is a brand of hormone replacement therapy (HRT) medicine. It’s used to relieve the symptoms of the menopause and contains a synthetic form of oestrogen; oestradiol.

There are three types of Evorel:

  • Evorel
  • Evorel Conti
  • Evorel Sequi

Whilst all of the above versions contain the synthetic hormone, oestradiol, Evorel Conti also contains norethisterone – a synthetic version of another female sex hormone; progesterone.

All versions of Evorel come as a patch that must be applied below the waist (often on the thighs or buttocks).

The type of Evorel that only contains oestrogen should only be used by women who’ve had a hysterectomy, as they don’t need to take progesterone alongside it. However, evorel conti is made with both female sex hormones, making it a safe option for women who do still have a womb, as the progesterone in the patch can reduce the risk of developing womb cancer.

Evorel can also be used to prevent or delay the onset of osteoporosis - a condition that post-menopausal women are more prone to than others.

How does Evorel work?

The hormone/s in Evorel (depending on which version you use) are absorbed by the skin and then into the bloodstream. This elevates levels of oestrogen (and progesterone in the case of evorel conti and evorel sequi) in your body to help relieve symptoms of the menopause such as:

  • Mood swings
  • Night sweats
  • Hot flushes
  • Vaginal dryness
  • Vaginal itching
  • Painful sex

All of these symptoms happen because of lower-than-normal oestrogen levels in your body. By building these back up to a level that you’re comfortable at, some (if not all) of the symptoms above can be relieved (or at least brought to a point where they’re bearable).

Some women might find the concept of using a patch for HRT strange in comparison to the traditional form of taking a pill each day. However, Evorel has proven to be just as effective, and is ideal for women who either don’t want to remember to take medication every day, or have difficulty swallowing tablets.

Can I take Evorel?

Evorel is a great choice for any woman considering using HRT. It’s something you only need to remember twice a week, and it’s not in pill form. However, as with all forms of HRT, there are some women that will need to avoid it completely, or have a chat with their doctor before starting treatment to see if it’s a safe option for them. Some women that need to have that talk with their GP include those who:

  • Are allergic to any of the ingredients in Evorel or Evorel Conti
  • Have a personal or family history of breast cancer
  • Have a personal or family history of oestrogen-sensitive cancers such as womb cancer and ovarian cancer
  • Are experiencing a thickening of the womb lining that’s currently untreated
  • Are experiencing unexplained vaginal bleeding
  • Have a history of blood clots
  • Have been diagnosed with liver disease
  • Have currently got or have previously had blocked arteries
  • Have a rare inherited condition called porphyria

Although the symptoms of the menopause can be unpleasant and sometimes even life-altering, if you have any of the above conditions, you may have to use alternative (and sometimes natural) methods to cope with some symptoms, as HRT might prove to be too dangerous for you.

What are the side effects of Evorel?

Evorel itself carries the same risks as other forms of HR, which include:

  • Breast cancer
  • Womb cancer
  • Ovarian cancer
  • Blood clots
  • Heart disease
  • Stroke
  • Potential memory loss if started after the age of 65

However, these apply to all forms of HRT and aren’t specific to Evorel. Some of the side effects that Evorel can cause include:

  • Skin irritation at application site
  • Breast pain
  • Rash
  • Itching
  • Dizziness
  • Headache
  • Nausea
  • Abdominal pain
  • Diarrhoea
  • General pain (muscles and joints)
  • Spotting/breakthrough bleeding
  • Weight gain

Some of the above symptoms might sound alarming, but it’s important to know that you might not experience any of them, or only to a mild degree. You should be regularly monitored by your doctor if you’re using HRT, so if you’re experiencing any side effects that worry you, please mention it as soon as possible.

How do you use Evorel?

Evorel is different to more traditional forms of hormone replacement therapy due to the fact that you receive the hormones via the skin, as they’re absorbed and passed into the bloodstream. This means that there aren’t any tablets to take.

Evorel patches must be changed twice a week, sticking to the same two change days each week. This means that one patch will be work for 3 days, and the next one for 4 or vice versa.

You should apply the patch to a hairless area below the waistline (avoiding areas where clothing might rub against the patch as this could affect how it works or peel it off completely). Many women choose to place it on their thighs or bum. On your change day, remove the patch and apply a new one to a different area. This makes sure that your skin doesn’t get irritated by placing the patch in the same spot each time. You should wait 7 days before applying another patch to the same area.

You shouldn’t stick evorel to an area above your waist, especially not the breasts, as this means that the hormones would be passed through the breast tissue, putting you more at risk of developing cancer.

You can carry on life as normal whilst wearing an Evorel patch. It’s safe to get wet and if it’s been applied right, water shouldn’t hinder its effectiveness or make it peel away.

If you use Evorel Sequi, you should apply the Evorel 50 patches for 2 weeks, and then the Evorel Conti patches for the next 2 weeks.

Don’t use cosmetics, lotions, cleansers or anything else to the area you’ll be applying Evorel to – it won’t stick as well and will peel off much more easily.

Does Evorel interact with any medications?

There are some medicines that Evorel might interact with, meaning that it could either affect how evorel works, or affect how the other medicine works. If you’re taking any of the medications that are in the following list, please make an appointment with your GP to see if Evorel is a safe option for you and your overall health.

  • Medicines for epilepsy such as phenobarbital, phenytoin and carbamazepine
  • Some drugs commonly used for infections such as rifampicin, rifabutin, nevirapine, efavirenz, ritonavir and nelfinavir
  • Bosentan
  • St John’s Wort
  • Lamotrigine

Will Evorel work as a contraceptive?

No. Even though it contains similar hormones to what are found in birth control medication, you shouldn’t use Evorel as a contraceptive method as the hormone levels aren’t at the right level to prevent pregnancy. If you’re still having periods and don’t want to become pregnant, you should use barrier methods such as condoms until your periods have completely stopped (if you haven’t had one in 12 months if you’re over 50).

How is my order shipped to me?

When an order is ready for shipping, it is collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Each order is assigned a tracking number, which will be emailed to you at the time of dispatch. Your medicine will be sent in plain and discreet packaging that’s eco-friendly. We do not include any branding on our packaging nor any labels which inform readers what type of product is contained within.

Advice on Addiction and Medication Restrictions

If you are at all worried or concerned about an addiction to any type of medication, we urge you to speak to a professional for help and advice. Below are links to organisations that can help.

  • Talk To Frank

  • NHS Help & Advice On Drug Addiction
  • Dosage Instructions
    A treatment cycle with Evorel Sequi is 28 days. During the first 14 days, one estradiol-only (Evorel 50) patch should be worn at all times, without interruption. During days 15-28, one estradiol + norethisterone (Evorel Conti) patch should be worn at all times, without interruption. A subsequent treatment cycle should follow immediately, without a treatment free interval.
    Active ingredients: Estradiol Hemihydrate, Norethisterone Acetate
    Write Your Own Review
    You're reviewing:Evorel Sequi
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    Evorel Sequi Dosage Quantity Cost Including Consultation
    Evorel Sequi 50mcg 24 Patches £65.99
    Evorel Sequi 50mcg 32 Patches £85.99

    Delivery Charges

    The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

    UK Standard Delivery, £1.99

    Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

    standard UK delivery within 3-5 working days

    Additional terms and conditions apply.

    UK Express Delivery, £2.99

    Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

    If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

    Additional terms and conditions apply.

    Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

    Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

    Additional terms and conditions apply.

    Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

    Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

    Additional terms and conditions apply.

    Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

    Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

    Additional terms and conditions apply.

    DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Saturday Delivery, £14.99

    Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply

    DPD Saturday Delivery, by 12:00am, £21.99

    Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Saturday Delivery, by 10:30am, £29.99

    Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply, please see below.

    US and outside the UK

    Unfortunately, we can't process orders from outside the UK at this time.


    Terms and Conditions

    Delivery options exclude Bank Holidays, public holidays and Sundays.All deliveries are subject to Doctor-4-u successfully receiving payment and prescription being approved by the doctor.

    All purchases require additional approval, which will involve completion of an online questionnaire and any subsequent approval.

    Active ingredients: Estradiol Hemihydrate, Norethisterone Acetate
    Out of stock