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Komboglyze

Komboglyze is a medication that’s prescribed to control the symptoms of type 2 diabetes. Whilst it can’t cure the condition, it can help to raise insulin levels and lower blood glucose, controlling and stabilising the condition.

Komboglyze is a mixture of saxagliptin and metformin, two anti-diabetic drugs which work in different ways to make sure the body utilises insulin and sugar in the most appropriate ways. Saxagliptin helps to increase the amount of insulin produced when blood sugar levels are high, and metformin helps to lower blood glucose levels. The two medications working together in one tablet makes Komboglyze an effective treatment for type 2 diabetes.

Komboglyze is usually taken twice a day with food; once in the morning and once in the evening. Your own GP will tell you what dose you need.

If you have type 1 diabetes, unfortunately this medication can’t help you with your condition. Please speak to your GP about how you can manage your symptoms and which treatments are available to you.

Last PIL Review Date: 21/01/2020

See Komboglyze 2.5/850mg Patient Information Leaflet

.

See Komboglyze 2.5/1000mg Patient Information Leaflet

£ 55.99 InStock
PLEASE CLICK HERE TO ANSWER SOME QUESTIONS ABOUT YOUR SYMPTOMS
Please note all the answers are reviewed by a doctor to assess eligibility
1
2

Please use a minimum of 1 words.

3
  • Allergy to saxagliptin or metformin
  • History of allergic reaction to other, similar medications that help to control your blood glucose levels
  • History of diabetic coma
  • Uncontrolled diabetes with hyperglycaemia, nausea, vomiting, diarrhoea, rapid weight loss, lactic acidosis or ketoacidosis
  • Severely reduced kidney function
  • Problems with your liver
  • Recent heart attack
  • Heart failure
  • Serious problems with your blood circulation
  • Breathing difficulties
  • Severe infection
  • Dehydrated
  • Drink an excessive amount of alcohol
  • History of pancreatic disease
  • Reduced immune system
4
  • Cimetidine
  • Ketoconazole
  • Bronchdilators for asthma
  • Diltiazem
  • Rifampicin
  • Corticosteroids
  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Diuretics
  • NSAIDs
  • COX-2 inhibitors
  • ACE inhibitors
  • Angiotensin II receptor antagonists
  • Other medicines to treat diabetes or control blood glucose levels (unless already prescribed by your GP in conjunction with saxagliptin and metformin)
  • Iodine injection for diagnostic imaging
5

Please use a minimum of 1 words.

6
7
  • You have an allergy to saxagliptin or metformin
  • You've used this treatment in the past and suffered from serious side effects
  • You're already taking saxagliptin or metformin in another medicinal form, or to treat any other condition
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What is Komboglyze?

Komboglyze is a brand of medication that’s used to control blood glucose in those with type 2 diabetes. It contains both metformin and saxagliptin, medicines which have previously been used separately to control the condition. Saxagliptin helps your body to produce more insulin when blood glucose levels are high, whilst metformin helps to lower blood glucose. The two drugs together are very effective at controlling the condition.

Can I take Komboglyze?

Komboglyze is an effective medication for those with type 2 diabetes, but there are still patients that may need to avoid the drug for various other reasons, including other pre-existing conditions. You should make an appointment with your own doctor before trying Komboglyze if any of the following conditions or problems apply to you:

  • Allergic to Komboglyze
  • History of allergic reaction to similar medicines
  • History of diabetic coma
  • Uncontrolled diabetes (with severely high blood glucose levels, nausea, vomiting, rapid weight loss, lactic acidosis and ketoacidosis)
  • Severely reduced kidney function
  • Problems with liver
  • Recent heart attack
  • Diagnosed heart failure
  • Issues with blood circulation
  • Severe infection
  • Dehydrated
  • Breast feeding
  • Pregnant
  • Regularly consuming large amounts of alcohol
  • Type 1 diabetes
  • Disease of the pancreas

If you aren’t sure if any of the above conditions apply to you, it might be a good idea to visit your doctor to request some tests to be done. However, if you know that none of the above apply to you, you can assume that it’s safe to use Komboglyze as long as you aren’t taking any of the medicines it might interact with.

What does Komboglyze interact with?

There are some other medicines that aren’t safe to use alongside Komboglyze, and you should read through the list to see if you’re already taking any of them. The potential interactions include:

  • Cimetidine
  • Ketoconazole
  • Bronchodilators
  • Diltiazem
  • Rifampicin
  • Corticosteroids
  • Carbamazepine
  • Diuretics
  • Anti-inflammatory medicines (including NSAIDs and COX-2 inhibitors)
  • ACE inhibitors
  • Angiotensin II receptor antagonists

If you aren’t sure if you’re taking any of these, please make a list of all the medicines you already take, and pop into your local pharmacy. They should be able to tell you if any of your current medications are on the list of potential interactions for Komboglyze.

If you do already take any of the drugs mentioned above, you should talk to your GP about whether it would be feasible to alter your medication regime, or if there are alternative treatments available to control your type 2 diabetes.

What are the side effects of Komboglyze?

Most medicines can cause side effects, and as Komboglyze contains two active medications, it’s certainly no exception to that rule. Komboglyze will only be prescribed to you if your GP thinks that it’s appropriate for your condition, but it’s also important to know that some of the side effects can be dangerous and/or severe. The main symptoms you should look out for are:

  • Lactic acidosis (vomiting, abdominal pain, muscle cramps, generally feeling unwell, severe fatigue, difficulty breathing, reduced body temperature and slow heart rate)
  • Severe and persistent abdominal pain
  • Severe joint pain

If you experience any of these side effects, you should go to your nearest A&E department or call 999. Lactic acidosis is a medical emergency, and the other side effects also require urgent treatment. It’s important to avoid drinking large amounts of alcohol whilst taking Komboglyze, as this can increase the risk of lactic acidosis.

Komboglyze can also cause other, much less serious side effects which include:

  • Headache
  • Muscle pain
  • Vomiting
  • Indigestion
  • Urinary tract infection
  • Infection of upper airways
  • Inflamed nose
  • Inflamed throat
  • Inflamed stomach/gut
  • Sinusitis
  • Flatulence
  • Dizziness
  • Fatigue
  • Joint pain
  • Erectile dysfunction

Whilst these side effects are more common and less serious than the ones that require urgent medical help, they might still affect you. You should always inform your own doctor if you experience side effects with any medication. They may be able to adjust your dose or suggest ways to deal with some of the side effects. In some cases, you might not be able to tolerate the drug and be prescribed something else to control your condition.

Can I drive while taking Komboglyze?

You should wait until you know how Komboglyze makes you feel first. As it can cause dizziness and fatigue, it might not be safe for you to operate a car or machinery. However, if you feel unaffected by the medicine and feel like your normal self, it should be safe to drive. People with diabetes often have to inform the DVLA of their condition due to the risk of hypoglycaemia which may be dangerous whilst driving. You should keep aware of the symptoms of low blood sugar, especially whilst on medication designed to lower your blood glucose levels. If at any point you feel as though you might be experiencing hypoglycemia, you should pull over when it’s safe to do so.

Can I take Komboglyze while pregnant?

As Komboglyze contains saxagliptin, it isn’t generally recommended to be used during pregnancy unless your doctor specifically states otherwise. Whilst pregnant, type 2 diabetes is usually controlled with insulin, and occasionally metformin. This might be a suitable option for you if you’re pregnant or trying to conceive.

You should also check with your GP if you’re able to take Komboglyze whilst breastfeeding or whether you should use alternative treatments.

Dosage Instructions
Take ONE tablet TWICE daily
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Komboglyze Dosage Quantity Cost Including Consultation
Komboglyze 2.5mg/850mg 56 Tablets £55.99
Komboglyze 2.5mg/1000mg 56 Tablets £55.99
Komboglyze 2.5mg/850mg 112 Tablets £87.99
Komboglyze 2.5mg/1000mg 112 Tablets £87.99
Komboglyze 2.5mg/850mg 168 Tablets £124.99
Komboglyze 2.5mg/1000mg 168 Tablets £124.99

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The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

UK Standard Delivery, £1.99

Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

standard UK delivery within 3-5 working days

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If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

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Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

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If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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DPD Saturday Delivery, £14.99

Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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DPD Saturday Delivery, by 12:00am, £21.99

Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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DPD Saturday Delivery, by 10:30am, £29.99

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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