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Nexium contains the active ingredient esomeprazole. It belongs to a group of medicines known as proton pump inhibitors. These medicines work by reducing the amount of acid produced in the stomach.

See Nexium (Esomeprazole) Tablets Patient Information Leaflet

Last PIL Review Date: 08/03/2019

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Nexium (Esomeprazole) Tablets

Medicines such as:

  • Omeprazole
  • Pantoprazole
  • Lansoprazole
  • Rabeprazole
  • Esomeprazole
  • NSAIDs (Non-steroidal anti-inflammatory drugs) e.g. ibuprofen
  • Ketoconazole, itraconazole, posaconazole or voriconazole (used to treat infections caused by a fungus)
  • Digoxin (used to treat heart problems)
  • Diazepam (used to treat anxiety, relax muscles or in epilepsy) 
  • Ulipristal (used as emergency contraception or treatment for fibroids) 
  • Phenytoin or fosphenytoin (used in epilepsy) 
  • Medicines that are used to thin your blood, such as warfarin or other Vitamin K blockers. 
  • Rifampicin (used to treat tuberculosis) 
  • Atazanavir, rilpivirine, tripranavir, saquinavir, nelfinavir, raltegravir (used to treat hiv infection)
  • Ledipasvir (used for hepatitis c treatment) 
  • Ciclosporin or tacrolimus (in cases of organ transplantation) 
  • St John's Wort (hypericum perforatum) (used to treat mild depression) 
  • Cilostazol (used to treat intermittent claudication) 
  • Clopidogrel (used to prevent blood clots (thrombi)) 
  • Vitamin B12, cyanocobalamin, hydroxocobalamin erlotinib, dabrafenib, lapatinib or pazopanib (for cancer treatment)
  • Clarithromycin (an antibiotic)
  • Methotrexate (for cancer or rheumatoid arthritis treatment) 
  • Escitalopram (an antidepressant) 
  • Clozapine (for schizophrenia)

Symptoms include:

  • Heartburn - a burning feeling in the chest just behind the breastbone that occurs after eating and lasts a few minutes to several hours
  • Chest pain, especially after bending over, lying down or eating
  • Burning in the throat, or hot, sour, acidic or salty-tasting fluid at the back of the throat feeling of food "sticking" in the middle of the chest or throat
  • Difficulty swallowing
  • Unintentional weight loss
  • Abdominal swelling
  • Persistent vomiting
  • Severe/persistent diarrhoea
  • Vomiting blood
  • Blood in your stools or black, tarry stools
  • Have iron deficiency anaemia
  • Severe liver problems
  • Osteoporosis
  • Liver problems
  • Gastric cancer
  • Hypomagnesaemia (low magnesium in the blood)
  • You will read the Patient Information Leaflet supplied with your medication
  • You will contact us and inform your GP of your medication if you experience any side effects of treatment, if you start new medication, or if your medical conditions change during treatment
  • The treatment is solely for your own use
  • You are over the age of 18 and you have entered your own information for our identity verification checks
  • You have answered all the above questions accurately and truthfully
  • You understand our doctors take your answers in good faith and base their prescribing decisions accordingly, and that incorrect information can be hazardous to your health
  • You will inform your own GP of this purchase if appropriate
  • You are happy for your consultation to be reviewed by a European doctor company, and as such it is not subject to CQC Registration or inspection in England. (Please note all of our medicines are dispensed from a fully licensed and regulated UK Pharmacy).
  • You have read our privacy policy, cookie policy, patient agreement, data sharing agreement and Terms & Conditions
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Nexium contains the active ingredient esomeprazole. It belongs to a group of medicines known as proton pump inhibitors. These medicines work by reducing the amount of acid produced in the stomach.

See Nexium (Esomeprazole) Tablets Patient Information Leaflet

Last PIL Review Date: 08/03/2019


What is Nexium and what does it do?

Nexium contains the active ingredient esomeprazole. It belongs to a group of medicines known as proton pump inhibitors. These medicines work by reducing the amount of acid produced in the stomach.

Nexium is primarily prescribed to treat conditions such as GORD and different types of ulcers of the stomach and gut.

When is Nexium prescribed?

Nexium may be prescribed to adult patients for the treatment of conditions associated with acid reflux and stomach ulcers. This includes the treatment of:

  • Pain, inflammation and heartburn caused by Gastroesophageal reflux disease (GERD).
  • Ulcers infected with Helicobacter pylori.
  • Stomach ulcers caused by NSAIDs (non-steroidal anti-inflammatory drugs, such as aspirin and ibuprofen).

Is Nexium suitable for my condition?

Nexium is likely to be suitable for your condition as long as you are not allergic to esomeprazole or any of the ingredients listed in the patient information leaflet, not allergic to any other proton pump inhibitors (such as pantoprazole, lansoprazole or omeprazole) and are not taking a medicine containing nelfinavir (used to treat HIV infection).

However, our doctors will always determine the suitability on a case by case basis. Special care must be taken if you have:

  • Severe liver problems.
  • Severe kidney problems.
  • Have ever had a skin or allergic reaction after taking any medicine to reduce the stomach acid.

What is the recommended dosage of Nexium?

You should follow the doctor’s instructions on how to take this medicine. The doses outlined below is for your reference only. The tablets can be taken with or without food and must be swallowed whole with a drink of water. Do not chew or crush the tablets.

Never exceed the stated dose.

Nexium doses for adults and the elderly:

For the treatment of heartburn caused by gastroesophageal reflux disease (GERD):

If it has been determined that your gullet (food pipe) has been slightly damaged, take 40mg per day for 4 weeks. If your gullet has not healed by the end of the course, the doctor may instruct you to take the same dose for another 4 weeks.

The recommended dose once you gullet has healed is 20mg per day.

If your gullet has not been damaged, take 20mg per day until the condition is under control.

For the treatment of ulcers caused by Helicobacter pylori infection, and to prevent it coming back:

The doctor may instruct you to take 20mg per day for 7 days in combination with antibiotics.

For the treatment of stomach ulcers caused by NSAIDs (non-steroidal anti-inflammatory drugs):

Take 20mg per day for 4 to 6 to 8 weeks. The doctor will instruct you on how long to take the tablets for.

For the prevention of stomach ulcers when taking NSAIDs

The doctor may recommend you to take 20mg per day while taking NSAIDs.

For the treatment of too much stomach acid caused by a growth in the pancreas (Zollinger-Ellison syndrome):

The doctor may recommend you to take 40mg twice per day.

Does Nexium cause any side effects?

Yes, Nexium may cause side effects. All medicines can cause side effects, although not everyone gets them. Common side effects from taking Nexium include:

  • Headache
  • Effects on your stomach, such as diarrhoea, stomach pain, constipation and flatulence.
  • Feeling sick or being sick (vomiting).

You should contact your GP or nearest clinic immediately if you notice any signs of an allergic reaction. Symptoms of an allergic reaction may include:

  • Sudden wheezing, swelling of your lips, tongue and throat or body, skin rash, fainting or difficulties swallowing.

Can I reduce the risk of getting side effects?

Yes. You should always read the patient information leaflet thoroughly before use as this can help reduce the risk of side effects and interactions between medicines. Below are a few things you can do:

  • While filling in the medical questionnaire, remember to include any other medicines you are taking. Nexium can affect how other medicines work, so it is important that you tell our doctors about all medicine you take. Don’t forget to also include over the counter medication and supplements.
  • Reduce the amount of alcohol you drink, or exclude alcohol completely until your course has finished. Alcohol can increase the risk of side effects of most drugs.

How do I buy Nexium online?

To legally and safely buy Nexium online you need a prescription from a GMC (General Medical Council) registered doctor. Our online doctor service allows you to request a prescription through a medical questionnaire.

Once you have chosen your medicine and submitted the questionnaire, it will be reviewed by one of our doctors. If suitable, the doctor will accept your request and a prescription will be issued. Your medicine will then be dispensed by our UK pharmacy and sent by tracked delivery to your chosen address. Your medicine is usually dispatched within 24 hours after ordering.

Dosage instructions
Take ONE tablet daily, or as directed by your doctor.