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Oestrogel

Oestrogel is a form of HRT for the treatment of menopausal symptoms. It differs from most forms of hormone replacement therapy due to it being in gel form that’s applied directly to the skin.

Oestrogel contains a synthetic version of the hormone oestrogen, which is absorbed through the skin and passes into the bloodstream, elevating levels of oestrogen in the body and relieving some of the distressing symptoms of the menopause.

Oestrogel should only be used on its own by women who don’t have a uterus (eg, those who’ve had a hysterectomy). Women that still have a womb will need to take some kind of progestogen to reduce the risk of womb cancer.

Oestrogel is a great alternative for women who struggle to swallow pills.

This medicine, along with many other forms of HRT can also help to prevent the development of osteoporosis. Whilst it isn’t used as a first line treatment, menopausal women already using HRT are able to use the same medicine to prevent the bone disorder.

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  • Jaundice (usually characterised by your skin or the whites of the eyes turning yellow)
  • Significantly increased blood pressure (you may notice headaches, dizziness, and feeling more tired)
  • New onset of migraine, which may be with or without aura
  • Chest pain that radiates to the arm and/or neck
  • Signs of a blood clot
  • Any breast changes such as dimpling, puckering, nipple discharge, or any other abnormality
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  • Epilepsy medications
  • Medicines for tuberculosis
  • HIV treatments
  • St John's Wort
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Please use a minimum of 1 words.

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  • You have an allergy to estradiol
  • You've used this treatment in the past and suffered with serious side effects 
  • You're already using a treatment that contains estradiol for any reason other than hormone replacement therapy
  • You still have your womb and are not using a progestogen alongside this oestrogen-only treatment
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What is Oestrogel?

Oestrogel is an external, topical treatment to relieve symptoms of the menopause. It contains a synthetic version of the hormone oestrogen; oestradiol. Oestrogel is a form of hormone replacement therapy (HRT), but it differs from its traditional counterparts due to the fact that it’s applied to the skin rather than ingested as a tablet.

Oestrogel can also be used to prevent the development of osteoporosis in women of menopausal age, though it isn’t usually used as a first line treatment for this. However, if a woman is already using oestrogel and is identified as being at risk of developing the condition, the treatment can be used as a “double edged sword” to treat both the symptoms of the menopause, and to prevent the onset of osteoporosis.

How does oestrogel work?

Some might find it strange that a topical gel can help to relieve symptoms of the menopause, as the traditional forms of HRT are usually in pill-form. However, the gel still contains a synthetic version of oestrogen, which when applied to the skin, is absorbed and passed into the bloodstream.

As oestrogen levels naturally deplete as a woman reaches menopausal age, the hormone in oestrogel helps to restore the body’s oestrogen levels to relieve symptoms such as:

  • Hot flushes
  • Night sweats
  • Mood swings
  • Vaginal dryness
  • Vaginal itching

HRT treatments such as oestrogel can greatly improve the quality of life for women who are experiencing the menopause. Whilst the symptoms aren’t life-threatening, they can certainly be life-altering, but with HRT, the process of going through “the change” can be made much more bearable.

Can I use oestrogel?

Oestrogel should only be used on its own as HRT treatment for women without a uterus, so for example, those who’ve previously had a hysterectomy. If you do still have a uterus, you can use oestrogel as long as you also take a progestogen for at least 12 days of each month. This is due to the fact that oestrogen on its own can increase your risk of developing womb cancer, yet when combined with a synthetic version of the hormone progesterone, the risk is reduced again. However, this isn’t necessary for women who’ve had their womb removed, as they’re no longer at risk of developing the cancer, and can safely use oestrogen on its own to treat the symptoms of the menopause.

In terms of health conditions, there are some women that need to be careful when thinking about using HRT. This doesn’t only apply to oestrogel, but for most forms of hormone replacement therapy. Some of the women that should avoid most forms of HRT are those who:

  • Have a personal or family history of breast cancer
  • Have a personal or family history of oestrogen-sensitive cancers such as womb or ovarian cancer
  • Have experienced unexplained vaginal pleading
  • Have an excessive thickening of the womb lining that has been left untreated
  • Have a history or increased risk of blood clots in a vein
  • Have a blood-clotting disorder
  • Have a disease that’s caused by blood clots in the arteries (for example, heart disease or stroke)
  • Have liver disease that hasn’t been treated, or where levels haven’t returned to normal
  • Have a rare inherited condition called porphyria
  • Are allergic to oestradiol or any of the ingredients in the medicine

There are also some groups of women that need to speak to their GP before considering using oestrogel or any other HRT medicines. These women may still be able to take the medication as long as they’re closely monitored. If you have any of the health conditions below and are considering starting treatment, please make an appointment with your GP:

  • Fibroids
  • Endometriosis
  • Endometrial hyperplasia
  • Increased risk of blood clots
  • Increased risk of oestrogen sensitive cancers such as womb cancer and ovarian cancer
  • High blood pressure
  • Liver disorder
  • Diabetes
  • Gallstones
  • Migraine headaches
  • Systematic lupus erythematosus
  • Epilepsy
  • High cholesterol
  • Fluid retention associated with the heart and kidneys

If you don’t have any of the above conditions or disorders, it should be safe to use oestrogel to manage your symptoms. However, remember that if you still have a womb, you’ll also need to take a progestogen.

What are the side effects of Oestrogel?

Most medicines can cause some unwanted side effects, but the most important thing is to determine whether the benefits of the medication outweighs the potential risks. Your GP will help you decide whether using oestrogel is the best thing for you, but it’s always good to be informed of the side effects. Whilst some of the symptoms on this list might sound alarming, it’s important to remember that you might not experience any of the side effects at all, or only to a minimal degree. Some of the most commonly reported symptoms associated with the use of oestrogel are:

  • Allergic reaction
  • Sudden chest pain
  • Chest pain that radiates to the arms and back
  • Difficulty breathing
  • Painful swelling and/or redness of the legs
  • Jaundice
  • Unexpected vaginal bleeding after you’ve been using oestrogel for a while, or once you stop treatment
  • Changes of the breasts
  • Painful menstrual periods
  • Unexplained migraine headaches
  • Worsened epilepsy
  • Rash with target-shaped reddening or sores (erythema multifame)

In addition to these side effects, most forms of HRT also carry the following risks:

  • Breast cancer
  • Oestrogen sensitive cancers
  • Blood clots
  • Heart disease
  • Stroke
  • Potential memory loss if started after the age of 65
  • Headaches
  • Nausea
  • Breast pain and tenderness
  • Menstrual cramps
  • Heavy menstrual bleeding
  • Weight changes
  • Water retention

It’s important to remember that these risks are only marginally increased with HRT, but please make an appointment with your GP if you have any concerns.

How do I use oestrogel?

Oestrogel comes in a pump. You’ll need to set the pump up for the first time you use it, as the first dose of gel it dispenses shouldn’t be used.

To set a new pump up, you should remove the stopper from the spout and press the plunger until a dose of gel is dispensed. You should discard of this first gel. You can now use the pump as normal.

When applying the gel, make sure you only apply it to either the shoulder and outer upper arm, or to the inner thighs. Don’t use it on or near the breasts, and use it far enough away from your genitals. Only apply to both arms or both legs, not all four together. Don’t apply to irritated or broken skin. Don’t let anyone other than yourself apply the gel, and thoroughly wash your hands after application.

Allow the gel to dry for around 5 minutes before putting clothes over the area of application, and avoid skin contact with anyone else (especially men and children) for at least an hour after application.

You should apply the gel once a day at the same time each day. Don’t take a double-dose if you’ve forgotten one and it’s less than 12 hours to your next application. Signs of an overdose include breast tension, nausea and vaginal bleeding.

Your pump must be discarded of once the plunger doesn’t return to its normal position. When this happens, start a new pump.

You should be reviewed by your GP once a year if you’re using any form of HRT.

How is my order shipped to me?

When an order is ready for shipping, it is collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Each order is assigned a tracking number, which will be emailed to you at the time of dispatch. Your medicine will be sent in plain and discreet packaging that’s eco-friendly. We do not include any branding on our packaging nor any labels which inform readers what type of product is contained within.

Advice on Addiction and Medication Restrictions

If you are at all worried or concerned about an addiction to any type of medication, we urge you to speak to a professional for help and advice. Below are links to organisations that can help.

  • Talk To Frank

  • NHS Help & Advice On Drug Addiction
  • Dosage Instructions
    Each metered dose (1 pump actuation) from the dispenser is 1.25 g of Oestrogel. Two pumps (2.5 g) of Oestrogel once daily (1.5 mg Estradiol) is the usual starting dose, which in the majority of women will provide effective relief of symptoms.
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    Delivery Charges

    The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

    UK Standard Delivery, £1.99

    Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

    standard UK delivery within 3-5 working days

    Additional terms and conditions apply.

    UK Express Delivery, £2.99

    Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

    If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

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    Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

    Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

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    Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

    Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

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    Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

    Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

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    DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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    DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Saturday Delivery, £14.99

    Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply

    DPD Saturday Delivery, by 12:00am, £21.99

    Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Saturday Delivery, by 10:30am, £29.99

    Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply, please see below.

    US and outside the UK

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    Delivery options exclude Bank Holidays, public holidays and Sundays.All deliveries are subject to Doctor-4-u successfully receiving payment and prescription being approved by the doctor.

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