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Ovitrelle

Ovitrelle is used for women undergoing assisted reproductive techniques to help them get pregnant when there is difficulty in achieving this naturally. Usually administered via an injection pen, this medication adds a hormone that encourages the body to trigger ovulation, a crucial process in making a woman fertile and allowing reproduction to ensue.



Ovitrelle 250 mcg/ 0.5 ml pre-filled pen Patient Information Leaflet

Ovitrelle 250 mcg/ 0.5 ml pre-filled syringe PIL

Last Patient Information Leaflet Review: 22/01/2020



This medicine is no longer available to request via our online service. If you are still having trouble with your symptoms please visit the NHS website for services in your area.

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What is Ovitrelle?

Ovitrelle is a medication that is used by women as part of fertility treatment to help them get pregnant when medical support is required. Ovitrelle is used alongside other medicines as part of the following fertility treatments:

  • To help develop and ripen several follicles (each containing an egg) in women using Assisted Reproductive Techniques such as ‘in vitro fertilisation’.
  • To help release an egg from the ovary in women who cannot produce eggs or produce too few eggs.

How does Ovitrelle work?

Ovitrelle contains an active substance called choriogonadotropin alfa. It is a laboratory-made substance that mimics a natural hormone called chorionic gonadotropin, which is involved during reproduction and fertility. This hormone is even sometimes informally referred to as the ‘pregnancy hormone’.

When the active ingredient is injected into the patient’s body, it triggers ovulation (the release of eggs by the ovaries) and the development of a special hormone-secreting structure on the ovary called the corpus luteum.

How do I use Ovitrelle?

If you are administering Ovitrelle to yourself, you should carefully read the instructions for use that should be included in the carton for this medication. The injection is meant to be given under the skin (subcutaneously) and the pre-filled pen the treatment comes in is for single use only. When Ovitrelle is injected, the used needle should be disposed of safely and the pen should be discarded.

How do I store Ovitrelle?

Ovitrelle should be stored in a refrigerator (2-8 degrees centigrade) until you’re ready to use this medication. Avoid freezing it or using this treatment if it is past its expiry date which is stated on the carton and possibly on the injection pen itself. Remember to keep this medicine out of both the sight and reach of children.

What are the side effects of Ovitrelle?

There are several potential side effects that Ovitrelle can cause, although not all patients will get them. The most common side effects associated with this treatment are headaches, tiredness and local reactions at the injection site, including pain, redness or swelling. Other, more troubling side effects are possible but also uncommon. If you do get any side effects, it’s best to talk to your doctor or pharmacist about them for advice.

You should stop using this medicine and see a doctor immediately if you experience any of these serious side effects:

  • Allergic reactions including swelling of your tongue, wheezing, serious breathing difficulties, and a fast or uneven pulse.
  • Lower abdominal pain combined with nausea or vomiting. These may be symptoms of Ovarian Hyperstimulation Syndrome (OHSS), meaning the ovaries are over-reacting to the treatment and large ovarian cysts have developed.
  • Serious blood clotting complications (thromboembolic events). This could be either connected or independent of OHSS. Signs of this issue include chest pain, breathlessness, stroke or heart attack.

Before starting this treatment, your doctor should assess the fertility of both yourself and your partner. Certain types of complications that can occur with pregnancies are more likely compared to typical natural births that are unassisted.

Besides the potential serious side effects mentioned before, the treatment does carry a small risk of causing an ectopic pregnancy (outside of the womb) if a woman has damaged fallopian tubes (which carry the egg from the ovary to the womb). Also, Assisted Reproductive Techniques including this medication increase the possibility of experiencing a miscarriage compared to the average woman. This treatment also increases the chances of being pregnant with more than one child at the same time (usually twins).

Can I use Ovitrelle?

Before you start using Ovitrelle, you should know that there are certain health conditions that may make taking this treatment a bad idea. Avoid using this medication if any of the following apply to you:

  • You have a tumour in a part of your brain called the hypothalamus or pituitary gland
  • You have large ovaries or sacs of fluid within the ovaries (ovarian cysts) which are unexplained
  • You have unexplained vaginal bleeding
  • You have cancer of your ovaries, womb or breast
  • You have had a pregnancy outside of your womb (extrauterine pregnancy) within the past few months
  • You have severe inflammation of your veins or blood clotting in your veins
  • You have a condition which typically makes a normal pregnancy impossible. Examples include menopause, early menopause (ovarian failure) or malformations of sexual organs.

If there is any other medication you are currently taking or have recently taken, inform your doctor about these and they will inform if they think complications could occur with using Ovitrelle.

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Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

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Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

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Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

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Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

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