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High Blood Pressure

Perindopril

Perindopril is a medicine that’s given to patients to lower blood pressure. It belongs to the family of medicines called ACE inhibitors, and works by allowing your blood vessels to dilate, making it easier for blood to be pumped around your body. It can also be given to patients suffering with heart failure. By default, Perindopril can prevent future strokes and heart attacks.

Perindopril can be given to patients that have already had a heart attack, and it also improves their rate of survival. It means that there’s less stress on the heart as the blood pressure is lowered.

Last PIL Review Date: 24/01/2020

See Perindopril Patient Information Leaflet

This medicine is not available to request via our online service. If you are still having trouble with your symptoms please visit the NHS website for services in your area.


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Dr. Diana Gall GMC No. 7685129

Dr Diana Gall graduated from medical school in 2005 and has since undertaken further intensive training in many different areas of medicine. Dr Diana has reached consultant level and has practiced medicine all over Europe.

Shamir Patel GPHC No. 2049338

Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

What is Perindopril?

Perindopril is a medicine that’s prescribed to treat high blood pressure, as well as heart failure. It can also be given to a patient after they’ve had a heart attack to improve their rate of survival.

Perindopril not only helps to lower blood pressure, but it can also reduce the risk of potential strokes and heart attacks due to the action that it causes in your body. Having high blood pressure can seriously increase your risk of experiencing these emergency problems, so Perindopril prevents them by default.

How does Perindopril work?

Perindopril is an ACE inhibitor, and it works in the same way as other, similar medicines. When you have high blood pressure, a hormone called angiotensin II causes the muscles surrounding the blood vessels to contract, making the vessels narrower and harder to pump blood through. This hormone is produced by angiotensin converting enzymes (ACE).

As an ACE inhibitor, Perindopril decreases the production of angiotensin II from the enzyme, and therefore reduces your blood pressure by making sure the blood vessels are able to widen.

Can I take Perindopril?

As Perindopril has quite a big effect on your body, there are certain people that are best avoiding it completely, or speaking to their GP beforehand. The people that should completely avoid using Perindopril are those who are:

  • Allergic to any ingredients of Perindopril or other ACE inhibitors
  • More than 3 months pregnant
  • Diabetic
  • Diagnosed with kidney problems

There are also some other conditions which will require you to speak to your GP before starting treatment. This is because it might be unsuitable for some conditions. These include:

  • Aortic stenosis
  • Hypertrophic cardiomyopathy
  • Renal artery stenosis
  • Other heart problems
  • A collagen vascular disease
  • Upcoming major surgery
  • Due to have LDL apheresis
  • Upcoming desensitisation treatment
  • Recent diarrhoea
  • Recent vomiting
  • Currently dehydrated
  • Being of black origin (those of black origin are more likely to develop angioedema)
  • Intolerance to some sugars
  • Taking an angiotensin II receptor blocker
  • Taking aliskiren
  • Taking racecadotril
  • Taking sirolimus
  • Taking everolimus
  • Taking temsirolimus
  • Taking any other mTor inhibitors.

You should inform your doctor if you think you may be pregnant, as it might also be best to avoid the medication in early pregnancy. They will be able to advise you on alternative treatment options during your pregnancy.

If any of the above conditions apply to you, you should make an appointment with your doctor to discuss your suitability for Perindopril. Just because you might have any of the above doesn’t necessarily mean you won’t be able to take Perindopril. However, your own GP may want to give you a lower dose than normal, or monitor you closely during your treatment.

Does Perindopril interact with any other medications?

There are some medicines that might interact with Perindopril, possibly increasing the risk or severity of side effects, or meaning that one of the medications works differently in your body. Sometimes, these interactions can be serious. If you’re already taking any of the following medicines, you should bring it up with your doctor and ask whether it’s safe for you to take Perindopril for your hypertension:

  • Other high blood pressure medicines
  • Aliskiren
  • Diuretics
  • Triamterene
  • Amiloride
  • Potassium supplements
  • Potassium-containing salt substitutes
  • Eplerenone
  • Spironolactone
  • Lithium
  • NSAIDs
  • Insulin
  • Metformin
  • Baclofen
  • Tricyclic antidepressants
  • Antipsychotics
  • Immunosuppressants
  • Trimethoprim
  • Estramustine
  • Allopurinol
  • Procainamide
  • Vasodilators
  • Nitrates
  • Heparin
  • Medicines for low blood pressure
  • Medicines for shock
  • Medicines for asthma
  • Gold salts
  • Medicines to help avoid rejection of transplanted organs
  • Some treatments for diarrhoea

If you aren’t sure whether any you’re taking any of the above medicines, it’s a good idea to either make a list or take your current medication packets in to a pharmacy and ask them to check if you can take Perindopril alongside them.

Always tell the doctor about any and all other medications you’re taking, including illegal drugs and OTC medicines such as ibuprofen and paracetamol.

If you’ve previously taken any of the medicines on this list, but don’t any more, you should still inform your doctor, telling them when you last took it.

What are the side effects of Perindopril?

We already know that Perindopril makes a big chance in the way your body works, so it’s to be expected that it carries some side effects with it. Before we look at some of the most common symptoms associated with taking perindopril, it’s important to know about the critical side effects that would require you to seek emergency treatment at a hospital. These include:

  • Angioedema (symptoms include swelling of the face, lips, tongue, throat and intestines, swelling of the skin, rash, difficulty breathing, conjunctivitis, abdominal pain, nausea, dizziness and fainting).
  • Allergic reaction (anaphylaxis)

You should dial 999 as soon as you notice these symptoms and tell the operator that you’re taking perindopril.

Some of the more common (and less critical) side effects include:

  • Headache
  • Dizziness
  • Vertigo
  • Pins and needles
  • Visual disturbances
  • Tinnitus
  • Lightheadedness (from low blood pressure)
  • Cough
  • Shortness of breath
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Other GI problems
  • Muscle cramps
  • Fatigue
  • Mood swings
  • Sleep disturbances
  • Bronchospasm
  • Dry mouth
  • Intense itching
  • Severe rash
  • Impotence
  • Kidney problems
  • Sweating
  • Palpitations
  • Tachycardia
  • Photosensitivity reaction
  • Joint pain
  • Feeling generally unwell
  • High blood level of potassium
  • Low level of sodium

The full list of side effects is available in the patient information leaflet that comes with your order of Perindopril. Always make sure you thoroughly read the patient information leaflet with any new medication so you’re fully aware of all of the potential side effects.

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