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HRT (Menopause)

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Premique

Premique is used for Hormone Replacement Therapy (HRT), adding two female hormones to reduce the symptoms that can occur during the menopause. Available in two strengths, these tablets are made by Pfizer and they are taken on a daily basis by patients prescribed them.

Premique PIL

Last PIL Review Date: 14/06/2019

Prices start from £24.99 for 84 tablets

£ 24.99 InStock
Please note a final decision on a suitable medicine for your condition will be made by our prescriber once you have completed a consultation PLEASE CLICK HERE TO ANSWER SOME QUESTIONS ABOUT YOUR SYMPTOMS
Please note all the answers are reviewed by a doctor to assess eligibility
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  • Jaundice (usually characterised by your skin or the whites of the eyes turning yellow)
  • Significantly increased blood pressure (you may notice headaches, dizziness, and feeling more tired)
  • New onset of migraine, which may be with or without aura
  • Chest pain that radiates to the arm and/or neck
  • Signs of a blood clot
  • Any breast changes such as dimpling, puckering, nipple discharge, or any other abnormality
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  • Epilepsy medications
  • Medicines for tuberculosis
  • HIV treatments
  • Metyrapone
  • Aminoglutethimide 
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Please use a minimum of 1 words.

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Please use a minimum of 1 words.

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  • You have an allergy to medroxyprogesterone or conjugated oestrogens
  • You've used this treatment in the past and suffered with serious side effects
  • You're already using a treatment that contains medroxyprogesterone or conjugated oestrogens for any reason other than hormone replacement therapy
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Dr Daniel Cichi has 20 years experience as a doctor and now he is a senior GP. He worked in A&E departments, GP surgeries and on cruise ships.

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Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

What is Premique?

Premique is a type of Hormone Replacement Therapy (HRT) which is used to relieve menopausal symptoms. This particular treatment is classed as a continuous combined form of HRT, containing two female hormones which work to restore hormone levels that have naturally fallen. There are two strengths Premique tablets can come in and the lower strength option is referred to as ‘Premique Low Dose’. This Low Dose version may be prescribed when a patient is using HRT for the first time or is sensitive to the potential side effects of HRT.

How does Premique work?

Premique tablets contain artificial versions of two female hormones known as oestrogen and progesterone. When a woman begins experiencing the menopause, the body’s natural production of oestrogen becomes much less, and it’s this change that can cause the symptoms associated with the menopause. For some women, the symptoms (which can include hot flushes, headaches and feelings of dryness in the vagina) can prove severe enough to affect quality of life.

The oestrogen contained in this medication helps to restore the hormone back to natural levels prior the menopause in order to relieve symptoms. The progesterone is used to maintain oestrogen at a suitable level and avoid an overdose of this hormone, which could create side effects. Combined HRT like Premique is used by patients that still have their womb, whereas those that have had a hysterectomy to remove their womb will normally take an oestrogen-only form of HRT.

How do I take Premique?

Whatever strength the tablets you’ve been prescribed are, the usual dose is one tablet every day. You’re meant to start taking this medication by taking the first tablet marked for the day of the week you’re on. Continue to take the tablets each day (preferably always around the same time) until all 28 tablets have been taken. Then start a new pack and repeat without pauses for as long as this treatment is required.

The tablets are meant to be swallowed whole so avoid trying to take off the coating or crushing or dividing these tablets, as you could affect the way the treatment works.

What are the side effects of Premique?

When you use Premique or other forms of HRT, side effects are possible but not every patient will experience any. The most common side effects experienced by users of this medication include the following:

  • Breast pain
  • Breakthrough bleeding or spotting
  • Swollen breasts or breast tenderness
  • Depression
  • Muscle and joint aches
  • Weight change (can increase or decrease)
  • Nipple discharge

Other side effects have the potential to appear but are also far less common compared to the ones mentioned above. Nevertheless, you should tell your doctor if you experience any side effects that cause a lot of discomfort. You should stop taking Premique and contact your doctor immediately if you experience any of the following:

  • An allergic reaction with symptoms including a swollen face, difficulty breathing and irritations on your skin
  • A migraine-type headache that hasn’t been experienced before
  • Signs of jaundice (yellowing of the skin or the whites of the eyes)
  • A significant increase in blood pressure

It has been found that women who use HRT are statistically more likely to get certain diseases compared to those who do not use such treatment. These diseases include:

  • Heart disease
  • Stroke
  • Blood clots
  • Breast cancer
  • Endometrial cancer (in the lining of the womb)
  • Ovarian cancer

Can I use Premique?

Not every woman will be able to use Premique or other types of HRT since certain diseases or medications can create complications with this treatment. You should avoid taking Premique if any of these health situations apply to you:

  • You have or have had breast cancer
  • You have endometrial cancer or another type of estrogen-dependent cancer
  • You have or have had a blood clot or blood circulation disorder
  • You have a heart condition such as angina or have previously had a heart attack
  • You have experienced unexplained vaginal bleeding
  • You have excessive thickening of the womb lining that is not being treated (endometrial hyperplasia)
  • You have or have had a liver disease
  • You have a rare blood problem called porphyria

Before taking this treatment, you should let your doctor or pharmacist know about other medication that you are currently taking or have recently used. It’s particularly important to highlight these if you have been using them:

  • An anticonvulsant to treat epilepsy (such as phenytoin or carbamazepine)
  • An anti-infective (such as rifabutin, nevirapine or rifampicin)
  • Metyrapone (usually used to treat Cushing’s syndrome)
  • Aminoglutethimide (usually treats breast cancer or Cushing’s syndrome)
  • An herbal preparation like St. John’s wort (Hypericum perforatum)

What if I take too much Premique?

If you accidentally take a larger dose of this medication than you’re meant to, it’s unlikely you will experience any serious problems. However, you could feel nauseous or experience other symptoms such as dizziness, abdominal pain, drowsiness or breast tenderness. A short period of vaginal bleeding may also be experienced.

What if I forget to take Premique?

If you forget to take a dose of this treatment, then take it as soon as you remember and carry on taking the remaining tablets at the usual time. Never take more than the recommended dose to make up for a missed dose. You shouldn’t have any major problems if you forget a dose, but a short period of light bleeding could occur as a consequence. The chances of this happening increase the more times you forget to take Premique.

How is my order shipped to me?

When an order is ready for shipping, it is collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Each order is assigned a tracking number, which will be emailed to you at the time of dispatch. Your medicine will be sent in plain and discreet packaging that’s eco-friendly. We do not include any branding on our packaging nor any labels which inform readers what type of product is contained within.

Advice on Addiction and Medication Restrictions

If you are at all worried or concerned about an addiction to any type of medication, we urge you to speak to a professional for help and advice. Below are links to organisations that can help.

  • Talk To Frank

  • NHS Help & Advice On Drug Addiction
  • Dosage Instructions
    One Premique tablet to be taken at the same time per day.
    Active ingredients: Medroxyprogesterone Acetate, Oestrogens, Conjugated
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    Premique Dosage Quantity Cost Including Consultation
    Premique 0.3mg 84 Tablets £24.99

    Delivery Charges

    The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

    UK Standard Delivery, £1.99

    Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

    standard UK delivery within 3-5 working days

    Additional terms and conditions apply.

    UK Express Delivery, £2.99

    Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

    If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

    Additional terms and conditions apply.

    Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

    Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

    Additional terms and conditions apply.

    Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

    Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

    Additional terms and conditions apply.

    Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

    Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

    Additional terms and conditions apply.

    DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

    Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Saturday Delivery, £14.99

    Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply

    DPD Saturday Delivery, by 12:00am, £21.99

    Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply.

    DPD Saturday Delivery, by 10:30am, £29.99

    Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

    If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

    Additional terms and conditions apply, please see below.

    US and outside the UK

    Unfortunately, we can't process orders from outside the UK at this time.


    Terms and Conditions

    Delivery options exclude Bank Holidays, public holidays and Sundays.All deliveries are subject to Doctor-4-u successfully receiving payment and prescription being approved by the doctor.

    All purchases require additional approval, which will involve completion of an online questionnaire and any subsequent approval.

    Active ingredients: Medroxyprogesterone Acetate, Oestrogens, Conjugated
    In stock