UK icon
UK Registered Pharmacy
head shoulders icon
Friendly Patient Support
padlocks icon
Confidential Service
Order in the next to receive order by

*select next day delivery at checkout. Subject to doctor approval

Trisequens

Trisequens is a brand of HRT medicine. It contains a naturally occurring form of oestrogen (estradiol) and a synthetic version of progesterone (norethisterone). The combination of two hormones means that it’s safe to be taken by women who still have a womb, as they need to take progesterone in addition to oestrogen to reduce their risk of developing endometrial cancer.

Trisequens is a sequential type of HRT, meaning that there are different amounts of hormones in each pill according to its colour. This ensures that you get an optimal dose of each hormone throughout the month without having to take any other medication to supplement it.

HRT should always be monitored by your doctor at least once a year.

Prices start from £42.00 for 84 tablets

£ 42 InStock
In stock
SKU
Trisequens
PLEASE CLICK HERE TO ANSWER SOME QUESTIONS ABOUT YOUR SYMPTOMS
Please note all the answers are reviewed by a doctor to assess eligibility
1
2
  • Kidney or liver problems
  • History of heart problems such as an irregular or fast heartbeat or angina
  • Epilepsy
3
4
  • Heart problems (including angina, chest pain, heart failure, irregular heart beats, heart attack, left-ventricular outflow obstruction, cardiomyopathy or valvular heart disease)
  • Stroke
  • Sight loss due to poor circulation, sight loss because of non-arteritic anterior ischemic optic neuropathy (NAION)
  • Blood problems (such as haemophilia, sickle cell anaemia, leukaemia, multiple myeloma)
  • Stomach ulcers
  • Liver problems
  • Kidney problems
  • An erection that lasted more than 4 hours
  • Any physical condition affecting the shape of the penis (e.g. angulation, Peyronie's disease and cavernosal fibrosis)
  • Inherited eye disease - retinitis pigmentosa
  • Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption
  • Any serious medical condition which may require immediate hospitalisation
5

Please use a minimum of 10 words.

6
7
8
  • Smears are usually needed every 3 years for women 25-49 yrs and every 5 years from 50-64 years
  • Smears may be needed more frequently if you have previously had an abnormal smear result
9

Please use a minimum of 10 words.

10
11

Please use a minimum of 10 words.

12
13
14

Please use a minimum of 10 words.

15
  • Gallstones
  • History of DVT
  • Diabetes
  • Migraines
  • High blood pressure

Please use a minimum of 10 words.

16

Please use a minimum of 10 words.

17

Please use a minimum of 10 words.

18
19
20
  • You will read the Patient Information Leaflet supplied with your medication
  • You will contact us and inform your GP of your medication if you experience any side effects of treatment, if you start new medication, or if your medical conditions change during treatment
  • The treatment is solely for your own use
  • You are over the age of 18 and you have entered your own information for our identity verification checks
  • You have answered all the above questions accurately and truthfully
  • You understand our doctors take your answers in good faith and base their prescribing decisions accordingly, and that incorrect information can be hazardous to your health
  • You will inform your own GP of this purchase if appropriate
  • You are happy for your consultation to be reviewed by a European doctor company, and as such it is not subject to CQC Registration or inspection in England. (Please note all of our medicines are dispensed from a fully licensed and regulated UK Pharmacy).
  • You have read our privacy policy, cookie policy, patient agreement, data sharing agreement and Terms & Conditions
Other Treatments Include
Online consulting and prescribing service
Dispensing of prescriptions and supply of medicine
Secure SSL Encryption

Dr. Diana Gall GMC No. 7685129

Dr Diana Gall graduated from medical school in 2005 and has since undertaken further intensive training in many different areas of medicine. Dr Driana has reached consultant level and has practiced medicine all over Europe.

Shamir Patel GPHC No. 2049338

Shamir is a well-respected pharmacist with extensive experience running online pharmacies in the UK.

What is Trisequens?

Trisequens is a form of hormone replacement therapy (HRT) that’s prescribed to postmenopausal women. Usually, it’s only prescribed if you had your last period more than 6 months ago, but if your symptoms are particularly bad, your doctor might prescribe them to you before then.

Trisequens can also help to prevent osteoporosis in postmenopausal women.

Trisequens contains two types of hormones, a natural oestrogen (estradiol) and a synthetic form of progesterone (norethisterone). This means that it’s safe to be taken by women who still have a womb, as it contains both types of hormones that they need.

Trisequens is slightly different to many forms of HRT, as it’s a cyclical, sequential version of the treatment. This means that there are three different pills containing different amounts of hormones that should be taken each day. The pills are colour coded as follows:

  • Blue: days 1-12. These only contain estradiol
  • White: days 13-22. As well as containing estradiol, these pills also contain norethisterone
  • Red: days 23-28. For the final 6 days, the red pills contain smaller amounts of estradiol

This sequential method of HRT ensures that you’re getting all of the hormones you need without having to take more than one pill per day.

How does Trisequens work?

During the menopause, your ovaries produce less oestrogen, meaning that you experience frustrating symptoms such as night sweats, hot flushes and mood swings amongst others.

Trisequens works in the same way to other HRT treatments that are available, by replacing the oestrogen in your body that your ovaries can no longer produce. This helps to reduce the symptoms you feel and hopefully gives you a better quality of life.

Progesterone is given to women who still have a womb, as taking oestrogen on its own can increase your risk of developing endometrial cancer, but when used in conjunction with progesterone, the risk is lowered again.

Can I take Trisequens?

As it’s a form of HRT, some women will need to find alternative treatments to ease their symptoms, as all forms of hormone replacement therapy include elevated risks of some serious health conditions.

Before you start treatment with HRT, you’ll need to sit with your doctor and talk about your personal and family history of certain medical conditions. Following this conversation, your GP will decide whether HRT is the right treatment for you or whether you should seek alternative therapies, as the increased risk of some serious problems may prove too dangerous considering your medical history. Some of the conditions and problems that might prevent you from taking Trisequens are:

  • Breast cancer
  • Endometrial cancer
  • Ovarian cancer
  • Unexplained vaginal bleeding
  • Excessive thickening of the womb lining
  • Blood clot in vein
  • Blood clotting disorder
  • Heart attack
  • Stroke
  • Angina
  • Liver disease
  • Allergy to any ingredients
  • Porphyria
  • Fibroids of the womb
  • Gallstones
  • SLE
  • Asthma
  • Diabetes
  • High cholesterol
  • High blood pressure
  • Migraines
  • Epilepsy
  • Otosclerosis
  • Lactose intolerance

If you know that you’ve been diagnosed with any of the above conditions, or know that you have al elevated risk of developing them due to family history, please make an appointment to talk to your doctor about how you can manage the symptoms of the menopause. For some of the conditions above, your doctor might still let you start treatment on Trisequens but they may want to monitor you more closely than someone without any of the above health problems. Women on HRT are usually monitored at least once a year, but for those at higher risk of some side effects or cancers, frequency of visits is often increased.

What are the side effects of Trisequens?

Trisequens contains two types of hormones, which can cause some unpleasant side effects, However, many women don’t experience any of the effects, and those that do often find that they’re more bearable than the symptoms of the menopause. It’s important to familiarise yourself with the symptoms that medicines can cause so you know what to expect. In the case of Trisequens, the most commonly reported symptoms associated with its use are:

  • Breast pain
  • Tender breasts
  • Irregular periods
  • Heavy periods
  • Headache
  • Weight gain
  • Vaginal inflammation
  • Thrush
  • Migraines
  • Depression
  • Nausea
  • Abdominal pain
  • Breast enlargement
  • Back pain
  • Leg cramps
  • Uterine fibroids
  • Swelling of the arms and legs

There are also some side effects that other forms of HRT can cause. There’s a chance that Trisequens can cause these due to them containing similar hormones. These are:

  • Discolouration of the skin
  • Painful and reddish skin nodules
  • Rash with target-shaped reddening.

You should immediately stop using Trisequens and make an urgent appointment with your doctor if you notice any of the following conditions after starting treatment:

  • Jaundice
  • Severe rise in blood pressure
  • New onset of migraines
  • If you become pregnant
  • Signs of a blood clot

It is still possible to get pregnant whilst using HRT and if your last period was less than 12 months ago. Although it contains similar hormones to many birth control pills, the dosage is different and you won’t be protected against pregnancy. If you don’t want to become pregnant, the best advice we can give is to use barrier methods such as condoms until you haven’t had a period for at least 12 months.

How do I take Trisequens?

Trisequens is really easy to take. As it’s sequential, you take one pill each day, preferably at the same time. Whilst it means that you need to remember to take medicine every day, it also means that you don’t have to take another pill for a few days to make sure you get progesterone into your system, as it’s already included in trisequens.

Each pack of trisequens contains 28 tablets; 12 blue, 10 white, and 6 red. They contain different amounts of both hormones as stated above.

  • On days 1-12, you should the blue pills
  • On days 13-22, you should take the white pills
  • On days 23-28, you should take the remaining 6 red pills.

It’s important to take the pills in the right order as changing it could cause a hormone imbalance again, and not work to its full potential.

Trisequens doesn’t need to be taken with food, but you should take all tablets with a glass of water to avoid the pill getting stuck in the oesophagus.

How long should I take Trisequens for?

This will depend on your symptoms. In all cases, women should be prescribed the lowest dose effective for the shortest amount of time possible, but this is something that your doctor will help you decide during a monitoring session.

How is my order shipped to me?

When an order is ready for shipping, it is collected and delivered by either the Royal Mail or DPD depending on your preference (or possibly your location or the item you ordered). Each order is assigned a tracking number, which will be emailed to you at the time of dispatch. Your medicine will be sent in plain and discreet packaging that’s eco-friendly. We do not include any branding on our packaging nor any labels which inform readers what type of product is contained within.

Dosage Instructions
No
One 28-day pack contains: 12 blue tablets (2 mg estradiol); 10 white pills (2mg estradiol and 1mg norethisterone); and 6 red tablets (1mg estradiol). They are taken once a day in sequence as directed.
Active ingredients: Estradiol Hemihydrate, norethisterone acetate
Trisequens Dosage Quantity Cost Including Consultation
Trisequens 2mg/1mg 84 Tablets £42.00
Write Your Own Review
You're reviewing:Trisequens

Delivery Charges

The following delivery methods are currently available within the UK: All orders are sent in discreet, plain packaging.

UK Standard Delivery, £1.99

Order before 12pm to have your order delivered using Royal Mail Tracked 48 Service

standard UK delivery within 3-5 working days

Additional terms and conditions apply.

UK Express Delivery, £2.99

Order before 12pm to have your order delivered using the Express delivery service* (deliveries are made Monday - Saturday)

If you order after 12pm, your order will be dispatched the next working day and will be with you within 48 hours once dispatched. This excludes weekends and bank holidays

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Anytime, £4.99 (This service includes Saturday)

Order before 12pm to have your order delivered using Royal Mail Special Delivery Service, which includes Saturday deliveries.

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Before 1pm, £7.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 1pm next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

Royal Mail Special Delivery Next Day Before 9am, £14.99 (This service includes Saturday)

Order before 12pm to have your order delivered before 9am next day using Royal Mail Special Delivery service, this also includes Saturday deliveries.

Additional terms and conditions apply.

DPD Next Day Delivery, £4.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 12 Noon, £9.99 (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 12 noon the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Next Day Delivery, by 10:30am, £14.99  (Monday - Friday only. This service does not include Saturday)

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am the following working day

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, £14.99

Orders signed by the doctor before 12 noon the day before will be delivered the following Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply

DPD Saturday Delivery, by 12:00am, £21.99

Orders signed by the doctor before 12 noon the day before will be delivered by 12:00am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply.

DPD Saturday Delivery, by 10:30am, £29.99

Orders signed by the doctor before 12 noon the day before will be delivered by 10:30am Saturday

If your order is signed by the doctor after 12 noon, your order will be delivered within 2 working days

Additional terms and conditions apply, please see below.

US and outside the UK

Unfortunately, we can't process orders from outside the UK at this time.


Terms and Conditions

Delivery options exclude Bank Holidays, public holidays and Sundays.All deliveries are subject to Doctor-4-u successfully receiving payment and prescription being approved by the doctor.

All purchases require additional approval, which will involve completion of an online questionnaire and any subsequent approval.

Active ingredients: Estradiol Hemihydrate, norethisterone acetate
No Questions